Progressive Irreversible Proprioceptive Piezo2 Channelopathy-Induced Lost Forced Peripheral Oscillatory Synchronization to the Hippocampal Oscillator May Explain the Onset of Amyotrophic Lateral Sclerosis Pathomechanism
Abstract
1. Introduction
2. Piezo2 Channelopathy, Piezo2–Piezo1 Crosstalk, and Syndecans
3. The Metabolic Switch
4. Additional Likely Role of Snydecan-3 and MyoD in ALS
5. Conclusions
6. Limitations
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Amyotrophic Lateral Sclerosis (ALS) | Delayed-Onset Muscle Soreness (DOMS) | |||
---|---|---|---|---|
Primary intrafusal damage phase | YES | Irreversible intrafusal proprioceptive terminal microdamage | YES | Transient intrafusal proprioceptive terminal microdamage |
YES | Irreversibly lost imposed movement-based low-frequency forcing oscillation from the Type Ia afferent signal due to irreversible Piezo2 channelopathy ** | YES | Transiently lost imposed movement-based low-frequency forcing oscillation from the Type Ia afferent signal due to transient Piezo2 channelopathy ** | |
NO | Lost NMDA receptor activation on spinal dorsal horn due to irreversibly lost glutamate vesicular release on type Ia proprioceptive neurons | YES | NMDA receptor activation on spinal dorsal horn due to impairment of the glutamate vesicular release on type Ia proprioceptive neurons | |
NO | Lost L-type calcium currents and nonspecific cationic currents in spinal dorsal horn due to lost Piezo2 functional at peripheral proprioceptive terminals | YES | L-type calcium currents and nonspecific cationic currents in spinal dorsal horn due to peripheral proprioceptive terminal Piezo2 channelopathy induced subthreshold imbalanced calcium currents | |
NO | Wide dynamic range (WDR) neuron activation | YES | WDR neuron activation | |
Soreness condition | Considered as a painless disease | DOMS lasting up to 7 days |
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Sonkodi, B. Progressive Irreversible Proprioceptive Piezo2 Channelopathy-Induced Lost Forced Peripheral Oscillatory Synchronization to the Hippocampal Oscillator May Explain the Onset of Amyotrophic Lateral Sclerosis Pathomechanism. Cells 2024, 13, 492. https://doi.org/10.3390/cells13060492
Sonkodi B. Progressive Irreversible Proprioceptive Piezo2 Channelopathy-Induced Lost Forced Peripheral Oscillatory Synchronization to the Hippocampal Oscillator May Explain the Onset of Amyotrophic Lateral Sclerosis Pathomechanism. Cells. 2024; 13(6):492. https://doi.org/10.3390/cells13060492
Chicago/Turabian StyleSonkodi, Balázs. 2024. "Progressive Irreversible Proprioceptive Piezo2 Channelopathy-Induced Lost Forced Peripheral Oscillatory Synchronization to the Hippocampal Oscillator May Explain the Onset of Amyotrophic Lateral Sclerosis Pathomechanism" Cells 13, no. 6: 492. https://doi.org/10.3390/cells13060492
APA StyleSonkodi, B. (2024). Progressive Irreversible Proprioceptive Piezo2 Channelopathy-Induced Lost Forced Peripheral Oscillatory Synchronization to the Hippocampal Oscillator May Explain the Onset of Amyotrophic Lateral Sclerosis Pathomechanism. Cells, 13(6), 492. https://doi.org/10.3390/cells13060492