WISP-1 Regulates Cardiac Fibrosis by Promoting Cardiac Fibroblasts’ Activation and Collagen Processing
Abstract
:1. Introduction
2. Materials and Methods
2.1. Cell Culture
2.2. In Vitro Sample Collection and Preparation
2.3. Western Blotting
2.4. Quantitative Polymerase Chain Reaction
2.5. Silencing RNA
2.6. Immunocytochemistry
2.7. Kinetic Cell Motility Assay
2.8. Animals
2.9. Infusion of Angiotensin II
2.10. Immunohistochemistry
2.11. Enzyme-Linked Immunosorbent Assay (ELISA)
2.12. Statistical Analysis
3. Results
3.1. WISP-1 Protein Induced Type I Collagen Processing
3.2. Silencing of ADAMTS-2 Inhibited WISP-1 Protein-Induced Type I Collagen Processing
3.3. WISP-1 Protein-Induced Type I Collagen Processing Is Independent of Collagenase MMPs
3.4. WISP-1 Protein Induced Akt Phosphorylation via Integrin β1/Focal Adhesion Kinase (FAK)/Integrin-Linked Kinase (ILK)
3.5. WISP-1 Protein Promoted HCFs Activation
3.6. WISP-1 Deficiency Mice Attenuated AngII-Induced Coronary Artery Perivascular Collagen Deposition
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Li, Z.; Williams, H.; Jackson, M.L.; Johnson, J.L.; George, S.J. WISP-1 Regulates Cardiac Fibrosis by Promoting Cardiac Fibroblasts’ Activation and Collagen Processing. Cells 2024, 13, 989. https://doi.org/10.3390/cells13110989
Li Z, Williams H, Jackson ML, Johnson JL, George SJ. WISP-1 Regulates Cardiac Fibrosis by Promoting Cardiac Fibroblasts’ Activation and Collagen Processing. Cells. 2024; 13(11):989. https://doi.org/10.3390/cells13110989
Chicago/Turabian StyleLi, Ze, Helen Williams, Molly L. Jackson, Jason L. Johnson, and Sarah J. George. 2024. "WISP-1 Regulates Cardiac Fibrosis by Promoting Cardiac Fibroblasts’ Activation and Collagen Processing" Cells 13, no. 11: 989. https://doi.org/10.3390/cells13110989