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Systematic Review

Raman Spectroscopy as a Neuromonitoring Tool in Traumatic Brain Injury: A Systematic Review and Clinical Perspectives

1
Neuroscience, Trauma and Ophthalmology, Institute of Inflammation and Ageing, University of Birmingham, Birmingham B15 2TT, UK
2
NIHR Surgical Reconstruction and Microbiology Research Centre, University Hospitals Birmingham, Birmingham B15 2TH, UK
3
School of Chemical Engineering, University of Birmingham, Birmingham B15 2TT, UK
4
Centre for Trauma Science Research, University of Birmingham, Birmingham B15 2TT, UK
*
Author to whom correspondence should be addressed.
Academic Editors: Andrew Chih Wei Huang, Seong Soo A. An, Bai Chuang Shyu, Muh-Shi Lin and Anna Kozłowska
Cells 2022, 11(7), 1227; https://doi.org/10.3390/cells11071227
Received: 17 March 2022 / Revised: 1 April 2022 / Accepted: 4 April 2022 / Published: 5 April 2022
Traumatic brain injury (TBI) is a significant global health problem, for which no disease-modifying therapeutics are currently available to improve survival and outcomes. Current neuromonitoring modalities are unable to reflect the complex and changing pathophysiological processes of the acute changes that occur after TBI. Raman spectroscopy (RS) is a powerful, label-free, optical tool which can provide detailed biochemical data in vivo. A systematic review of the literature is presented of available evidence for the use of RS in TBI. Seven research studies met the inclusion/exclusion criteria with all studies being performed in pre-clinical models. None of the studies reported the in vivo application of RS, with spectral acquisition performed ex vivo and one performed in vitro. Four further studies were included that related to the use of RS in analogous brain injury models, and a further five utilised RS in ex vivo biofluid studies for diagnosis or monitoring of TBI. RS is identified as a potential means to identify injury severity and metabolic dysfunction which may hold translational value. In relation to the available evidence, the translational potentials and barriers are discussed. This systematic review supports the further translational development of RS in TBI to fully ascertain its potential for enhancing patient care. View Full-Text
Keywords: traumatic brain injury; neuromonitoring; Raman spectroscopy; point-of-care diagnostics; neuroinflammation; oxidative stress; metabolic dysfunction traumatic brain injury; neuromonitoring; Raman spectroscopy; point-of-care diagnostics; neuroinflammation; oxidative stress; metabolic dysfunction
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MDPI and ACS Style

Stevens, A.R.; Stickland, C.A.; Harris, G.; Ahmed, Z.; Goldberg Oppenheimer, P.; Belli, A.; Davies, D.J. Raman Spectroscopy as a Neuromonitoring Tool in Traumatic Brain Injury: A Systematic Review and Clinical Perspectives. Cells 2022, 11, 1227. https://doi.org/10.3390/cells11071227

AMA Style

Stevens AR, Stickland CA, Harris G, Ahmed Z, Goldberg Oppenheimer P, Belli A, Davies DJ. Raman Spectroscopy as a Neuromonitoring Tool in Traumatic Brain Injury: A Systematic Review and Clinical Perspectives. Cells. 2022; 11(7):1227. https://doi.org/10.3390/cells11071227

Chicago/Turabian Style

Stevens, Andrew R., Clarissa A. Stickland, Georgia Harris, Zubair Ahmed, Pola Goldberg Oppenheimer, Antonio Belli, and David J. Davies. 2022. "Raman Spectroscopy as a Neuromonitoring Tool in Traumatic Brain Injury: A Systematic Review and Clinical Perspectives" Cells 11, no. 7: 1227. https://doi.org/10.3390/cells11071227

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