What’s in a Gene? The Outstanding Diversity of MAPT
Abstract
:1. Introduction
2. Alternative Splicing: A Force of Diversity
3. Tau Alternative Splicing: Diversity of Forms
3.1. Central Nervous System Isoforms: Meet the Classics
3.2. Big Tau: A Giant Outsider
3.3. Black Sheep: Isoforms including Exon 6
3.4. W-Tau: The Rara Avis
4. Tau Alternative Splicing: Diversity of Functions
4.1. The Projection Domain: Tau’s Versatile N-Terminal End and the Extension of Big Tau
4.2. Proline-Rich Region and Isoforms Including Exon 6
4.3. Microtubule-Binding Domain: A Repetitive Region
4.4. W-Tau: The Uncharted Territory of Novel Isoforms and New Mechanisms
4.5. The Interplay: Interaction between Functional Regions
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Ruiz-Gabarre, D.; Carnero-Espejo, A.; Ávila, J.; García-Escudero, V. What’s in a Gene? The Outstanding Diversity of MAPT. Cells 2022, 11, 840. https://doi.org/10.3390/cells11050840
Ruiz-Gabarre D, Carnero-Espejo A, Ávila J, García-Escudero V. What’s in a Gene? The Outstanding Diversity of MAPT. Cells. 2022; 11(5):840. https://doi.org/10.3390/cells11050840
Chicago/Turabian StyleRuiz-Gabarre, Daniel, Almudena Carnero-Espejo, Jesús Ávila, and Vega García-Escudero. 2022. "What’s in a Gene? The Outstanding Diversity of MAPT" Cells 11, no. 5: 840. https://doi.org/10.3390/cells11050840