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Article

Aging Activates the Immune System and Alters the Regenerative Capacity in the Zebrafish Heart

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Molecular Genetics Laboratory, Leibniz Institute on Aging—Fritz Lipmann Institute (FLI), 07745 Jena, Germany
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Core Facility Imaging, 07745 Jena, Germany
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Core Facility Life Science Computing, 07735 Jena, Germany
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Core Facility DNA Sequencing, 07745 Jena, Germany
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Core Service Histology/Pathology/EM, Leibniz Institute on Aging—Fritz Lipmann Institute (FLI), 07745 Jena, Germany
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Institute of Biochemistry and Biophysics, Friedrich-Schiller-University Jena, 07745 Jena, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Juan Pablo de Rivero Vaccari
Cells 2022, 11(3), 345; https://doi.org/10.3390/cells11030345
Received: 1 November 2021 / Revised: 13 January 2022 / Accepted: 15 January 2022 / Published: 20 January 2022
(This article belongs to the Section Cellular Aging)
Age-associated organ failure and degenerative diseases have a major impact on human health. Cardiovascular dysfunction has an increasing prevalence with age and is one of the leading causes of death. In contrast to humans, zebrafish have extraordinary regeneration capacities of complex organs including the heart. In addition, zebrafish has recently become a model organism in research on aging. Here, we have compared the ventricular transcriptome as well as the regenerative capacity after cryoinjury of old and young zebrafish hearts. We identified the immune system as activated in old ventricles and found muscle organization to deteriorate upon aging. Our data show an accumulation of immune cells, mostly macrophages, in the old zebrafish ventricle. Those immune cells not only increased in numbers but also showed morphological and behavioral changes with age. Our data further suggest that the regenerative response to cardiac injury is generally impaired and much more variable in old fish. Collagen in the wound area was already significantly enriched in old fish at 7 days post injury. Taken together, these data indicate an ‘inflammaging’-like process in the zebrafish heart and suggest a change in regenerative response in the old. View Full-Text
Keywords: aging; zebrafish heart; age-dependent regeneration; immune cells; cryoinjury aging; zebrafish heart; age-dependent regeneration; immune cells; cryoinjury
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MDPI and ACS Style

Reuter, H.; Perner, B.; Wahl, F.; Rohde, L.; Koch, P.; Groth, M.; Buder, K.; Englert, C. Aging Activates the Immune System and Alters the Regenerative Capacity in the Zebrafish Heart. Cells 2022, 11, 345. https://doi.org/10.3390/cells11030345

AMA Style

Reuter H, Perner B, Wahl F, Rohde L, Koch P, Groth M, Buder K, Englert C. Aging Activates the Immune System and Alters the Regenerative Capacity in the Zebrafish Heart. Cells. 2022; 11(3):345. https://doi.org/10.3390/cells11030345

Chicago/Turabian Style

Reuter, Hanna, Birgit Perner, Florian Wahl, Luise Rohde, Philipp Koch, Marco Groth, Katrin Buder, and Christoph Englert. 2022. "Aging Activates the Immune System and Alters the Regenerative Capacity in the Zebrafish Heart" Cells 11, no. 3: 345. https://doi.org/10.3390/cells11030345

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