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Article

Role of Periostin and Nuclear Factor-κB Interplay in the Development of Diabetic Nephropathy

1
Unite Mixte de Recherche Scientific 1155, Institut National de la Sante et de la Recherche Medicale, Tenon Hospital, 75020 Paris, France
2
Faculty of Medicine, Sorbonne University, 75020 Paris, France
3
Department of Nephrology, University Hospital Regensburg, D-93053 Regensburg, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Sudhiranjan Gupta
Cells 2022, 11(14), 2212; https://doi.org/10.3390/cells11142212
Received: 31 May 2022 / Revised: 11 July 2022 / Accepted: 12 July 2022 / Published: 15 July 2022
Diabetic nephropathy (DN) remains the most common reason for end-stage renal disease and a leading cause of kidney replacement therapy. Multifactorial pathophysiological mechanisms underlie the development of DN. Among the signalling pathways involved, nuclear factor-κB (NF-κB) plays a key role in pathogenesis triggering inflammation, oxidative stress and fibrosis. Recent evidence shows that periostin, a matricellular protein, is involved in the development of renal glomerular diseases through interaction with NF-κB signalling. The aim of the present study is to investigate the contribution of periostin and its interaction with NF-κB in DN development. To this end, we used the BTBR ob/ob mice model of diabetes type 2, and we applied transcriptomic analysis, immunostaining and methods quantifying protein and mRNA expressions. We found that increased periostin expression was correlated with decreased renal function, advanced stage renal damage and fibrosis, and NF-κB activation. Subsequently, we identified novel pathways and genes regulated by the NF-κB-periostin interaction which are involved in the mechanisms of progression of DN. Some of these genes, such as FGF1 and GDF15, have the potential to be new biomarkers and/or targets for the therapy of DN. View Full-Text
Keywords: periostin; chronic kidney disease; NF-κB; inflammation; fibrosis; diabetic mice periostin; chronic kidney disease; NF-κB; inflammation; fibrosis; diabetic mice
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MDPI and ACS Style

Abbad, L.; Prakoura, N.; Michon, A.; Chalghoumi, R.; Reichelt-Wurm, S.; Banas, M.C.; Chatziantoniou, C. Role of Periostin and Nuclear Factor-κB Interplay in the Development of Diabetic Nephropathy. Cells 2022, 11, 2212. https://doi.org/10.3390/cells11142212

AMA Style

Abbad L, Prakoura N, Michon A, Chalghoumi R, Reichelt-Wurm S, Banas MC, Chatziantoniou C. Role of Periostin and Nuclear Factor-κB Interplay in the Development of Diabetic Nephropathy. Cells. 2022; 11(14):2212. https://doi.org/10.3390/cells11142212

Chicago/Turabian Style

Abbad, Lilia, Niki Prakoura, Arthur Michon, Rym Chalghoumi, Simone Reichelt-Wurm, Miriam C. Banas, and Christos Chatziantoniou. 2022. "Role of Periostin and Nuclear Factor-κB Interplay in the Development of Diabetic Nephropathy" Cells 11, no. 14: 2212. https://doi.org/10.3390/cells11142212

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