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Mesenchymal Stem Cells in Embryo-Maternal Communication under Healthy Conditions or Viral Infections: Lessons from a Bovine Model

Department of Animal Reproduction, National Institute for Agriculture and Food Research and Technology (INIA), CSIC, 28040 Madrid, Spain
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Academic Editor: Selim Kuçi
Cells 2022, 11(12), 1858; https://doi.org/10.3390/cells11121858
Received: 5 May 2022 / Revised: 1 June 2022 / Accepted: 6 June 2022 / Published: 7 June 2022
Bovine mesenchymal stem cells are a relevant cell population found in the maternal reproductive tract that exhibits the immunomodulation capacity required to prevent embryo rejection. The phenotypic plasticity showed by both endometrial mesenchymal stem cells (eMSC) and embryonic trophoblast through mesenchymal to epithelial transition and epithelial to mesenchymal transition, respectively, is essential for embryo implantation. Embryonic trophoblast maintains active crosstalk via EVs and soluble proteins with eMSC and peripheral blood MSC (pbMSC) to ensure the retention of eMSC in case of pregnancy and induce the chemotaxis of pbMSC, critical for successful implantation. Early pregnancy-related proteins and angiogenic markers are detected as cargo in EVs and the soluble fraction of the embryonic trophectoderm secretome. The pattern of protein secretion in trophectoderm-EVs changes depending on their epithelial or mesenchymal phenotype and due to the uptake of MSC EVs. However, the changes in this EV-mediated communication between maternal and embryonic MSC populations infected by viruses that cause abortions in cattle are poorly understood. They are critical in the investigation of reproductive viral pathologies. View Full-Text
Keywords: mesenchymal stromal cells; extracellular vesicles; early pregnancy; embryo; trophectoderm mesenchymal stromal cells; extracellular vesicles; early pregnancy; embryo; trophectoderm
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MDPI and ACS Style

Calle, A.; Ramírez, M.Á. Mesenchymal Stem Cells in Embryo-Maternal Communication under Healthy Conditions or Viral Infections: Lessons from a Bovine Model. Cells 2022, 11, 1858. https://doi.org/10.3390/cells11121858

AMA Style

Calle A, Ramírez MÁ. Mesenchymal Stem Cells in Embryo-Maternal Communication under Healthy Conditions or Viral Infections: Lessons from a Bovine Model. Cells. 2022; 11(12):1858. https://doi.org/10.3390/cells11121858

Chicago/Turabian Style

Calle, Alexandra, and Miguel Ángel Ramírez. 2022. "Mesenchymal Stem Cells in Embryo-Maternal Communication under Healthy Conditions or Viral Infections: Lessons from a Bovine Model" Cells 11, no. 12: 1858. https://doi.org/10.3390/cells11121858

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