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Review

Emerging Lysosomal Functions for Photoreceptor Cell Homeostasis and Survival

by 1 and 1,2,*
1
Department of Biology, University of Naples Federico II, Strada Vicinale Cupa Cinthia, 26, 80126 Naples, Italy
2
Telethon Institute of Genetics and Medicine, Via Campi Flegrei 34, 80078 Pozzuoli, Italy
*
Author to whom correspondence should be addressed.
Academic Editors: Paolo Bernardi, Luca Scorrano and Gerardo Z. Lederkremer
Cells 2022, 11(1), 60; https://doi.org/10.3390/cells11010060
Received: 31 October 2021 / Revised: 20 December 2021 / Accepted: 23 December 2021 / Published: 26 December 2021
(This article belongs to the Special Issue 10th Anniversary of Cells—Advances in Organelle Function)
Lysosomes are membrane-bound cell organelles that respond to nutrient changes and are implicated in cell homeostasis and clearance mechanisms, allowing effective adaptation to specific cellular needs. The relevance of the lysosome has been elucidated in a number of different contexts. Of these, the retina represents an interesting scenario to appreciate the various functions of this organelle in both physiological and pathological conditions. Growing evidence suggests a role for lysosome-related mechanisms in retinal degeneration. Abnormal lysosomal activation or inhibition has dramatic consequences on photoreceptor cell homeostasis and impacts extensive cellular function, which in turn affects vision. Based on these findings, a series of therapeutic methods targeting lysosomal processes could offer treatment for blindness conditions. Here, we review the recent findings on membrane trafficking, subcellular organization, mechanisms by which lysosome/autophagy pathway impairment affects photoreceptor cell homeostasis and the recent advances on developing efficient lysosomal-based therapies for retinal disorders. View Full-Text
Keywords: autophagy; photoreceptors; lysosome; retinal degeneration; membrane trafficking autophagy; photoreceptors; lysosome; retinal degeneration; membrane trafficking
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MDPI and ACS Style

Santo, M.; Conte, I. Emerging Lysosomal Functions for Photoreceptor Cell Homeostasis and Survival. Cells 2022, 11, 60. https://doi.org/10.3390/cells11010060

AMA Style

Santo M, Conte I. Emerging Lysosomal Functions for Photoreceptor Cell Homeostasis and Survival. Cells. 2022; 11(1):60. https://doi.org/10.3390/cells11010060

Chicago/Turabian Style

Santo, Manuela, and Ivan Conte. 2022. "Emerging Lysosomal Functions for Photoreceptor Cell Homeostasis and Survival" Cells 11, no. 1: 60. https://doi.org/10.3390/cells11010060

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