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Translating Treg Therapy for Inflammatory Bowel Disease in Humanized Mice

1
Biomedical Parasitology and Nano-Immunology Lab, Division of Cell Biology and Immunology, CSIR-Institute of Microbial Technology (IMTECH), Chandigarh 160036, India
2
BERPDC Department, CSIR-Institute of Microbial Technology (IMTECH), Chandigarh 160036, India
3
Institute of Science, Nirma University, Ahmedabad, Gujarat 382481, India
*
Authors to whom correspondence should be addressed.
Co-first author.
Academic Editor: Alessandro Poggi
Cells 2021, 10(8), 1847; https://doi.org/10.3390/cells10081847
Received: 7 May 2021 / Revised: 6 July 2021 / Accepted: 7 July 2021 / Published: 21 July 2021
(This article belongs to the Special Issue 10th Anniversary of Cells—Advances in Cellular Immunology)
Crohn’s disease and ulcerative colitis, two major forms of inflammatory bowel disease (IBD) in humans, afflicted in genetically predisposed individuals due to dysregulated immune response directed against constituents of gut flora. The defective immune responses mounted against the regulatory mechanisms amplify and maintain the IBD-induced mucosal inflammation. Therefore, restoring the balance between inflammatory and anti-inflammatory immunepathways in the gut may contribute to halting the IBD-associated tissue-damaging immune response. Phenotypic and functional characterization of various immune-suppressive T cells (regulatory T cells; Tregs) over the last decade has been used to optimize the procedures for in vitro expansion of these cells for developing therapeutic interventional strategies. In this paper, we review the mechanisms of action and functional importance of Tregs during the pathogenesis of IBD and modulating the disease induced inflammation as well as role of mouse models including humanized mice repopulated with the human immune system (HIS) to study the IBD. “Humanized” mouse models provide new tools to analyze human Treg ontogeny, immunobiology, and therapy and the role of Tregs in developing interventional strategies against IBD. Overall, humanized mouse models replicate the human conditions and prove a viable tool to study molecular functions of human Tregs to harness their therapeutic potential. View Full-Text
Keywords: humanized mice; inflammatory bowels disease; Crohn’s disease; ulcerative colitis; human immune system; regulatory T cells humanized mice; inflammatory bowels disease; Crohn’s disease; ulcerative colitis; human immune system; regulatory T cells
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MDPI and ACS Style

Negi, S.; Saini, S.; Tandel, N.; Sahu, K.; Mishra, R.P.N.; Tyagi, R.K. Translating Treg Therapy for Inflammatory Bowel Disease in Humanized Mice. Cells 2021, 10, 1847. https://doi.org/10.3390/cells10081847

AMA Style

Negi S, Saini S, Tandel N, Sahu K, Mishra RPN, Tyagi RK. Translating Treg Therapy for Inflammatory Bowel Disease in Humanized Mice. Cells. 2021; 10(8):1847. https://doi.org/10.3390/cells10081847

Chicago/Turabian Style

Negi, Sushmita, Sheetal Saini, Nikunj Tandel, Kiran Sahu, Ravi P.N. Mishra, and Rajeev K. Tyagi. 2021. "Translating Treg Therapy for Inflammatory Bowel Disease in Humanized Mice" Cells 10, no. 8: 1847. https://doi.org/10.3390/cells10081847

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