Negative Regulation of FGFR (Fibroblast Growth Factor Receptor) Signaling
Abstract
1. Introduction
2. Endocytosis
3. Phosphatases
4. Negative Regulatory Proteins
5. Negative Feedback Phosphorylations
6. Summary
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
AP2 | Adaptor protein 2 |
CBL | Casitas B-lineage lymphoma |
CHIP | Carboxyl terminus of HSP70-interacting protein |
CIE | Clathrin-independent endocytosis |
CK1 | Casein kinase 1 |
CLIC/GEEC | Clathrin-independent carriers/GPI-enriched early endosomal compartments |
CME | Clathrin-mediated endocytosis |
DUSP6 | Dual-specificity phosphatase 6 |
DYRK1A | Dual-specificity tyrosine phosphorylation-regulated kinase 1A |
Eps | Epidermal growth factor receptor kinase substrate |
ERK 1/2 | Extracellular signal-regulated kinase 1/2 |
ESCRT | Endosomal sorting complex required for transport |
Esyt2 | Extended synaptotagmin-2 |
FEME | Fast endophilin-mediated endocytosis |
FGF | Fibroblast growth factor |
FGFR | Fibroblast growth factor receptor |
FRS2 | FGFR substrate 2 |
Grb2/14 | Growth factor receptor-bound 2/14 |
HIF | Hypoxia-inducible factor |
HRS | Hepatocyte growth factor-regulated tyrosine kinase substrate |
Hsp90 | Heat shock protein 90 |
MAPK | Mitogen-activated protein kinase |
MEK | Mitogen-activated protein kinase kinase |
MKP3 | MAPK phosphatase 3 |
NBR1 | Neighbor of BRCA1 gene 1 protein |
NCAM | Neural cell adhesion molecules |
NEDD4 | Neural precursor cell expressed developmentally down-regulated protein 4 |
NEGR1 | Neuronal growth regulator 1NF-1 Neurofibromin |
PI3K | Phosphatidylinositol-4,5-bisphosphate 3-kinase |
PKC | Protein kinase C |
PLCγ | Phospholipase Cγ |
PP2A | Protein phosphatase 2A |
PTB | Phosphotyrosine binding |
PTP | Protein tyrosine phosphatase |
PTPN1/2/11 | Protein tyrosine phosphatase non-receptor type 1/2/11 |
PTPRG | Protein tyrosine phosphatase receptor type G |
RasGAP | Ras GTPase activating protein |
RSK2 | Ribosomal s6 kinase 2 |
RTK | Receptor tyrosine kinase |
SEF | Similar expression to Fgf |
SH3BP4 | SH3-binding protein 4 |
SHIP2 | Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase |
SHP1/2 | Src homology region 2 domain-containing phosphatase 1/2 |
Sos1 | Son of sevenless homolog 1 |
SPRED | Sprouty related with EVH1 (Ena/VASP homology 1) |
SPRY | Sprouty |
STAM 1 | Signal transducing adaptor molecule 1 |
STAT | Signal transducer and activator of transcription |
TESK1 | Testicular protein kinase 1 |
TGN | Trans Golgi network |
TSG101 | Tumor susceptibility gene 101 protein |
VHL | von Hippel-Lindau protein |
VPS4 | Vacuolar protein sorting-associated protein 4 |
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Szybowska, P.; Kostas, M.; Wesche, J.; Haugsten, E.M.; Wiedlocha, A. Negative Regulation of FGFR (Fibroblast Growth Factor Receptor) Signaling. Cells 2021, 10, 1342. https://doi.org/10.3390/cells10061342
Szybowska P, Kostas M, Wesche J, Haugsten EM, Wiedlocha A. Negative Regulation of FGFR (Fibroblast Growth Factor Receptor) Signaling. Cells. 2021; 10(6):1342. https://doi.org/10.3390/cells10061342
Chicago/Turabian StyleSzybowska, Patrycja, Michal Kostas, Jørgen Wesche, Ellen Margrethe Haugsten, and Antoni Wiedlocha. 2021. "Negative Regulation of FGFR (Fibroblast Growth Factor Receptor) Signaling" Cells 10, no. 6: 1342. https://doi.org/10.3390/cells10061342
APA StyleSzybowska, P., Kostas, M., Wesche, J., Haugsten, E. M., & Wiedlocha, A. (2021). Negative Regulation of FGFR (Fibroblast Growth Factor Receptor) Signaling. Cells, 10(6), 1342. https://doi.org/10.3390/cells10061342