Next Article in Journal
Crosstalk of Multi-Omics Platforms with Plants of Therapeutic Importance
Next Article in Special Issue
Eritoran Attenuates Hepatic Inflammation and Fibrosis in Mice with Chronic Liver Injury
Previous Article in Journal
Recurrent HBV Integration Targets as Potential Drivers in Hepatocellular Carcinoma
Previous Article in Special Issue
Modulation of microRNome by Human Cytomegalovirus and Human Herpesvirus 6 Infection in Human Dermal Fibroblasts: Possible Significance in the Induction of Fibrosis in Systemic Sclerosis
Article

Lack of Relationship between Fibrosis-Related Biomarkers and Cardiac Magnetic Resonance-Assessed Replacement and Interstitial Fibrosis in Dilated Cardiomyopathy

1
Department of Cardiac and Vascular Diseases, Jagiellonian University Medical College, John Paul II Hospital, Pradnicka St. 80, 31-202 Krakow, Poland
2
Department of Molecular Biology, John Paul II Hospital, Prądnicka St. 80, 31-202 Krakow, Poland
3
Department of Radiology, John Paul II Hospital, Pradnicka Street 80, 31-202 Krakow, Poland
4
Students’ Scientific Group at Department of Cardiac and Vascular Diseases, Jagiellonian University Collegium Medicum, John Paul II Hospital, 31-202 Krakow, Poland
5
Faculty of Medicine and Health Sciences, Andrzej Frycz Modrzewski Cracow University, 31-202 Krakow, Poland
*
Author to whom correspondence should be addressed.
Academic Editors: Maurizio Onisto and Valentina Masola
Cells 2021, 10(6), 1295; https://doi.org/10.3390/cells10061295
Received: 28 April 2021 / Revised: 19 May 2021 / Accepted: 20 May 2021 / Published: 23 May 2021
(This article belongs to the Special Issue Molecular Mechanisms in Organ Fibrosis)
The relationship between circulating fibrosis-related molecules and magnetic resonance-assessed cardiac fibrosis in dilated cardiomyopathy (DCM) is poorly understood. To compare circulating biomarkers between DCM patients with high and low fibrosis burdens, we performed a prospective, single-center, observational study. The study population was composed of 100 DCM patients (87 male, mean age 45.2 ± 11.8 years, mean ejection fraction 29.7% ± 10.1%). Replacement fibrosis was quantified by means of late gadolinium enhancement (LGE), whereas interstitial fibrosis was assessed via extracellular volume (ECV). Plasma concentrations of cardiotrophin-1, growth differentiation factor-15, platelet-derived growth factor, procollagen I C-terminal propeptide, procollagen III N-terminal propeptide, and C-terminal telopeptide of type I collagen were measured. There were 44% patients with LGE and the median ECV was 27.7%. None of analyzed fibrosis serum biomarkers were associated with the LGE or ECV, whereas NT-proBNP was independently associated with both LGE and ECV, and troponin T was associated with ECV. None of the circulating fibrosis markers differentiated between DCM patients with and without replacement fibrosis, or patients stratified according to median ECV. However, cardiac-specific markers, such as NT-proBNP and hs-TnT, were associated with fibrosis. Levels of circulating markers of fibrosis seem to have no utility in the diagnosis and monitoring of cardiac fibrosis in DCM. View Full-Text
Keywords: dilated cardiomyopathy; replacement fibrosis; interstitial fibrosis; biomarkers; collagen dilated cardiomyopathy; replacement fibrosis; interstitial fibrosis; biomarkers; collagen
Show Figures

Graphical abstract

MDPI and ACS Style

Rubiś, P.; Dziewięcka, E.; Szymańska, M.; Banyś, R.; Urbańczyk-Zawadzka, M.; Krupiński, M.; Mielnik, M.; Wiśniowska-Śmiałek, S.; Karabinowska, A.; Podolec, P.; Winiarczyk, M.; Gliniak, M.; Kaciczak, M.; Robak, J.; Karapetyan, A.; Wypasek, E. Lack of Relationship between Fibrosis-Related Biomarkers and Cardiac Magnetic Resonance-Assessed Replacement and Interstitial Fibrosis in Dilated Cardiomyopathy. Cells 2021, 10, 1295. https://doi.org/10.3390/cells10061295

AMA Style

Rubiś P, Dziewięcka E, Szymańska M, Banyś R, Urbańczyk-Zawadzka M, Krupiński M, Mielnik M, Wiśniowska-Śmiałek S, Karabinowska A, Podolec P, Winiarczyk M, Gliniak M, Kaciczak M, Robak J, Karapetyan A, Wypasek E. Lack of Relationship between Fibrosis-Related Biomarkers and Cardiac Magnetic Resonance-Assessed Replacement and Interstitial Fibrosis in Dilated Cardiomyopathy. Cells. 2021; 10(6):1295. https://doi.org/10.3390/cells10061295

Chicago/Turabian Style

Rubiś, Paweł, Ewa Dziewięcka, Magdalena Szymańska, Robert Banyś, Małgorzata Urbańczyk-Zawadzka, Maciej Krupiński, Małgorzata Mielnik, Sylwia Wiśniowska-Śmiałek, Aleksandra Karabinowska, Piotr Podolec, Mateusz Winiarczyk, Matylda Gliniak, Monika Kaciczak, Jan Robak, Arman Karapetyan, and Ewa Wypasek. 2021. "Lack of Relationship between Fibrosis-Related Biomarkers and Cardiac Magnetic Resonance-Assessed Replacement and Interstitial Fibrosis in Dilated Cardiomyopathy" Cells 10, no. 6: 1295. https://doi.org/10.3390/cells10061295

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop