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Article

Innate and Adaptive Immune Genes Associated with MERS-CoV Infection in Dromedaries

1
Research Institute of Wildlife Ecology, Department of Interdisciplinary Life Sciences, University of Veterinary Medicine Vienna, 1210 Vienna, Austria
2
Department of Animal Genetics, University of Veterinary Sciences Brno, 61242 Brno, Czech Republic
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RG Animal Immunogenomics, Ceitec Vetuni, 61242 Brno, Czech Republic
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College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai 505055, United Arab Emirates
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Viral Zoonoses, Emerging and Vector-Borne Infections Group, Institute of Virology, University of Veterinary Medicine Vienna, 1210 Vienna, Austria
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Center for Virology, Medical University of Vienna, 1090 Vienna, Austria
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Al Ain City Municipality, Al Ain 15258, United Arab Emirates
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The Sir Martin Evans Building, Cardiff School of Biosciences, Cardiff University, Museum Ave, Cardiff CF10 3AX, UK
*
Author to whom correspondence should be addressed.
Academic Editor: Marc Servant
Cells 2021, 10(6), 1291; https://doi.org/10.3390/cells10061291
Received: 23 March 2021 / Revised: 18 May 2021 / Accepted: 18 May 2021 / Published: 23 May 2021
The recent SARS-CoV-2 pandemic has refocused attention to the betacoronaviruses, only eight years after the emergence of another zoonotic betacoronavirus, the Middle East respiratory syndrome coronavirus (MERS-CoV). While the wild source of SARS-CoV-2 may be disputed, for MERS-CoV, dromedaries are considered as source of zoonotic human infections. Testing 100 immune-response genes in 121 dromedaries from United Arab Emirates (UAE) for potential association with present MERS-CoV infection, we identified candidate genes with important functions in the adaptive, MHC-class I (HLA-A-24-like) and II (HLA-DPB1-like), and innate immune response (PTPN4, MAGOHB), and in cilia coating the respiratory tract (DNAH7). Some of these genes previously have been associated with viral replication in SARS-CoV-1/-2 in humans, others have an important role in the movement of bronchial cilia. These results suggest similar host genetic pathways associated with these betacoronaviruses, although further work is required to better understand the MERS-CoV disease dynamics in both dromedaries and humans. View Full-Text
Keywords: coronavirus; immune response genes; Old World camels; in-solution hybridization capture; zoonosis coronavirus; immune response genes; Old World camels; in-solution hybridization capture; zoonosis
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MDPI and ACS Style

Lado, S.; Elbers, J.P.; Plasil, M.; Loney, T.; Weidinger, P.; Camp, J.V.; Kolodziejek, J.; Futas, J.; Kannan, D.A.; Orozco-terWengel, P.; Horin, P.; Nowotny, N.; Burger, P.A. Innate and Adaptive Immune Genes Associated with MERS-CoV Infection in Dromedaries. Cells 2021, 10, 1291. https://doi.org/10.3390/cells10061291

AMA Style

Lado S, Elbers JP, Plasil M, Loney T, Weidinger P, Camp JV, Kolodziejek J, Futas J, Kannan DA, Orozco-terWengel P, Horin P, Nowotny N, Burger PA. Innate and Adaptive Immune Genes Associated with MERS-CoV Infection in Dromedaries. Cells. 2021; 10(6):1291. https://doi.org/10.3390/cells10061291

Chicago/Turabian Style

Lado, Sara, Jean P. Elbers, Martin Plasil, Tom Loney, Pia Weidinger, Jeremy V. Camp, Jolanta Kolodziejek, Jan Futas, Dafalla A. Kannan, Pablo Orozco-terWengel, Petr Horin, Norbert Nowotny, and Pamela A. Burger 2021. "Innate and Adaptive Immune Genes Associated with MERS-CoV Infection in Dromedaries" Cells 10, no. 6: 1291. https://doi.org/10.3390/cells10061291

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