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Single-Cell Analysis
Open AccessReview

A Review of Single-Cell Adhesion Force Kinetics and Applications

Department of Engineering Design, Indian Institute of Technology Madras, Chennai 600036, Tamil Nadu, India
Department of Biosystems Engineering, Kangwon National University, Chuncheon-Si, Gangwon-Do 24341, Korea
Department of Mechanical Engineering, Toyohashi University of Technology, 1-1 Hibarigaoka, Tempaku-cho, Toyohashi, Aichi 441-8580, Japan
Author to whom correspondence should be addressed.
Academic Editor: Daniel Bouvard
Cells 2021, 10(3), 577;
Received: 28 January 2021 / Revised: 1 March 2021 / Accepted: 2 March 2021 / Published: 5 March 2021
(This article belongs to the Special Issue Single Cell Analysis 2.0)
Cells exert, sense, and respond to the different physical forces through diverse mechanisms and translating them into biochemical signals. The adhesion of cells is crucial in various developmental functions, such as to maintain tissue morphogenesis and homeostasis and activate critical signaling pathways regulating survival, migration, gene expression, and differentiation. More importantly, any mutations of adhesion receptors can lead to developmental disorders and diseases. Thus, it is essential to understand the regulation of cell adhesion during development and its contribution to various conditions with the help of quantitative methods. The techniques involved in offering different functionalities such as surface imaging to detect forces present at the cell-matrix and deliver quantitative parameters will help characterize the changes for various diseases. Here, we have briefly reviewed single-cell mechanical properties for mechanotransduction studies using standard and recently developed techniques. This is used to functionalize from the measurement of cellular deformability to the quantification of the interaction forces generated by a cell and exerted on its surroundings at single-cell with attachment and detachment events. The adhesive force measurement for single-cell microorganisms and single-molecules is emphasized as well. This focused review should be useful in laying out experiments which would bring the method to a broader range of research in the future. View Full-Text
Keywords: single-cell adhesion; mechanotransduction; microbial cell adhesion; single-molecule adhesion single-cell adhesion; mechanotransduction; microbial cell adhesion; single-molecule adhesion
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MDPI and ACS Style

Shinde, A.; Illath, K.; Gupta, P.; Shinde, P.; Lim, K.-T.; Nagai, M.; Santra, T.S. A Review of Single-Cell Adhesion Force Kinetics and Applications. Cells 2021, 10, 577.

AMA Style

Shinde A, Illath K, Gupta P, Shinde P, Lim K-T, Nagai M, Santra TS. A Review of Single-Cell Adhesion Force Kinetics and Applications. Cells. 2021; 10(3):577.

Chicago/Turabian Style

Shinde, Ashwini; Illath, Kavitha; Gupta, Pallavi; Shinde, Pallavi; Lim, Ki-Taek; Nagai, Moeto; Santra, Tuhin S. 2021. "A Review of Single-Cell Adhesion Force Kinetics and Applications" Cells 10, no. 3: 577.

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