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Targeting Mitochondrial Metabolism as a Strategy to Treat Senescence

Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon 22012, Korea
Department of Medical Sciences, Catholic Kwandong University College of Medicine, Incheon 22711, Korea
The Future Life & Society Research Center, Chonnam National University, Gwangju 61186, Korea
Authors to whom correspondence should be addressed.
Academic Editor: David Sebastián
Cells 2021, 10(11), 3003;
Received: 5 October 2021 / Revised: 2 November 2021 / Accepted: 2 November 2021 / Published: 3 November 2021
(This article belongs to the Special Issue Mitochondrial Fitness in Health and Disease)
Mitochondria are one of organelles that undergo significant changes associated with senescence. An increase in mitochondrial size is observed in senescent cells, and this increase is ascribed to the accumulation of dysfunctional mitochondria that generate excessive reactive oxygen species (ROS). Such dysfunctional mitochondria are prime targets for ROS-induced damage, which leads to the deterioration of oxidative phosphorylation and increased dependence on glycolysis as an energy source. Based on findings indicating that senescent cells exhibit mitochondrial metabolic alterations, a strategy to induce mitochondrial metabolic reprogramming has been proposed to treat aging and age-related diseases. In this review, we discuss senescence-related mitochondrial changes and consequent mitochondrial metabolic alterations. We assess the significance of mitochondrial metabolic reprogramming for senescence regulation and propose the appropriate control of mitochondrial metabolism to ameliorate senescence. Learning how to regulate mitochondrial metabolism will provide knowledge for the control of aging and age-related pathologies. Further research focusing on mitochondrial metabolic reprogramming will be an important guide for the development of anti-aging therapies, and will provide novel strategies for anti-aging interventions. View Full-Text
Keywords: mitochondrial metabolic reprogramming; mitochondria; ROS; senescence amelioration mitochondrial metabolic reprogramming; mitochondria; ROS; senescence amelioration
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MDPI and ACS Style

Lee, Y.H.; Park, J.Y.; Lee, H.; Song, E.S.; Kuk, M.U.; Joo, J.; Oh, S.; Kwon, H.W.; Park, J.T.; Park, S.C. Targeting Mitochondrial Metabolism as a Strategy to Treat Senescence. Cells 2021, 10, 3003.

AMA Style

Lee YH, Park JY, Lee H, Song ES, Kuk MU, Joo J, Oh S, Kwon HW, Park JT, Park SC. Targeting Mitochondrial Metabolism as a Strategy to Treat Senescence. Cells. 2021; 10(11):3003.

Chicago/Turabian Style

Lee, Yun H., Ji Y. Park, Haneur Lee, Eun S. Song, Myeong U. Kuk, Junghyun Joo, Sekyung Oh, Hyung W. Kwon, Joon T. Park, and Sang C. Park. 2021. "Targeting Mitochondrial Metabolism as a Strategy to Treat Senescence" Cells 10, no. 11: 3003.

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