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Clinical Applications of Cell-Scaffold Constructs for Bone Regeneration Therapy

Department of Restorative Dentistry, Division of Operative Dentistry, Graduate School of Dentistry, Tohoku University, Sendai 980-8575, Japan
OsteRenatos Ltd., Sendai Capital Tower 2F, 4-10-3 Central, Aoba-ku, Sendai 980-0021, Japan
National Institute of Advanced Industrial Science and Technology, 2266-98 Anagahora, Nagoya 463-8560, Japan
Department of Oral Science, Division of Oral Biochemistry, Graduate School of Dentistry, Kanagawa Dental University, Yokosuka 238-8580, Japan
Author to whom correspondence should be addressed.
Academic Editors: Friedrich Jung, Michael Raghunath and Anna Blocki
Cells 2021, 10(10), 2687;
Received: 13 August 2021 / Revised: 20 September 2021 / Accepted: 1 October 2021 / Published: 8 October 2021
(This article belongs to the Collection Advances in Cell Culture and Tissue Engineering)
Bone tissue engineering (BTE) is a process of combining live osteoblast progenitors with a biocompatible scaffold to produce a biological substitute that can integrate into host bone tissue and recover its function. Mesenchymal stem cells (MSCs) are the most researched post-natal stem cells because they have self-renewal properties and a multi-differentiation capacity that can give rise to various cell lineages, including osteoblasts. BTE technology utilizes a combination of MSCs and biodegradable scaffold material, which provides a suitable environment for functional bone recovery and has been developed as a therapeutic approach to bone regeneration. Although prior clinical trials of BTE approaches have shown promising results, the regeneration of large bone defects is still an unmet medical need in patients that have suffered a significant loss of bone function. In this present review, we discuss the osteogenic potential of MSCs in bone tissue engineering and propose the use of immature osteoblasts, which can differentiate into osteoblasts upon transplantation, as an alternative cell source for regeneration in large bone defects. View Full-Text
Keywords: bone tissue engineering; MSCs; osteoblasts; scaffolds bone tissue engineering; MSCs; osteoblasts; scaffolds
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MDPI and ACS Style

Venkataiah, V.S.; Yahata, Y.; Kitagawa, A.; Inagaki, M.; Kakiuchi, Y.; Nakano, M.; Suzuki, S.; Handa, K.; Saito, M. Clinical Applications of Cell-Scaffold Constructs for Bone Regeneration Therapy. Cells 2021, 10, 2687.

AMA Style

Venkataiah VS, Yahata Y, Kitagawa A, Inagaki M, Kakiuchi Y, Nakano M, Suzuki S, Handa K, Saito M. Clinical Applications of Cell-Scaffold Constructs for Bone Regeneration Therapy. Cells. 2021; 10(10):2687.

Chicago/Turabian Style

Venkataiah, Venkata Suresh, Yoshio Yahata, Akira Kitagawa, Masahiko Inagaki, Yusuke Kakiuchi, Masato Nakano, Shigeto Suzuki, Keisuke Handa, and Masahiro Saito. 2021. "Clinical Applications of Cell-Scaffold Constructs for Bone Regeneration Therapy" Cells 10, no. 10: 2687.

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