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Open AccessArticle

CD112 Regulates Angiogenesis and T Cell Entry into the Spleen

1
Institute of Pharmaceutical Sciences, ETH Zurich, Vladimir-Prelog-Weg 1-5/10, CH-8093 Zurich, Switzerland
2
Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Chuo-ku, Kobe 650-0047, Japan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Cells 2021, 10(1), 169; https://doi.org/10.3390/cells10010169
Received: 4 December 2020 / Revised: 8 January 2021 / Accepted: 11 January 2021 / Published: 15 January 2021
Junctional adhesion proteins play important roles in controlling angiogenesis, vascular permeability and leukocyte trafficking. CD112 (nectin-2) belongs to the immunoglobulin superfamily and was shown to engage in homophilic and heterophilic interactions with a variety of binding partners expressed on endothelial cells and on leukocytes. Recent in vitro studies suggested that CD112 regulates human endothelial cell migration and proliferation as well as transendothelial migration of leukocytes. However, so far, the role of CD112 in endothelial cell biology and in leukocyte trafficking has not been elucidated in vivo. We found CD112 to be expressed by lymphatic and blood endothelial cells in different murine tissues. In CD112-deficient mice, the blood vessel coverage in the retina and spleen was significantly enhanced. In functional in vitro studies, a blockade of CD112 modulated endothelial cell migration and significantly enhanced endothelial tube formation. An antibody-based blockade of CD112 also significantly reduced T cell transmigration across endothelial monolayers in vitro. Moreover, T cell homing to the spleen was significantly reduced in CD112-deficient mice. Overall, our results identify CD112 as a regulator of angiogenic processes in vivo and demonstrate a novel role for CD112 in T cell entry into the spleen. View Full-Text
Keywords: nectin-2; blood vessels; angiogenesis; spleen; T cell homing nectin-2; blood vessels; angiogenesis; spleen; T cell homing
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MDPI and ACS Style

Russo, E.; Runge, P.; Haghayegh Jahromi, N.; Naboth, H.; Landtwing, A.; Montecchi, R.; Leicht, N.; Hunter, M.C.; Takai, Y.; Halin, C. CD112 Regulates Angiogenesis and T Cell Entry into the Spleen. Cells 2021, 10, 169. https://doi.org/10.3390/cells10010169

AMA Style

Russo E, Runge P, Haghayegh Jahromi N, Naboth H, Landtwing A, Montecchi R, Leicht N, Hunter MC, Takai Y, Halin C. CD112 Regulates Angiogenesis and T Cell Entry into the Spleen. Cells. 2021; 10(1):169. https://doi.org/10.3390/cells10010169

Chicago/Turabian Style

Russo, Erica; Runge, Peter; Haghayegh Jahromi, Neda; Naboth, Heidi; Landtwing, Angela; Montecchi, Riccardo; Leicht, Noémie; Hunter, Morgan C.; Takai, Yoshimi; Halin, Cornelia. 2021. "CD112 Regulates Angiogenesis and T Cell Entry into the Spleen" Cells 10, no. 1: 169. https://doi.org/10.3390/cells10010169

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