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Enhancement of Wound Healing in Normal and Diabetic Mice by Topical Application of Amorphous Polyphosphate. Superior Effect of a Host–Guest Composite Material Composed of Collagen (Host) and Polyphosphate (Guest)

1
ERC Advanced Investigator Grant Research Group at the Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Mainz, Duesbergweg 6, 55128 Mainz, Germany
2
Fidelta Ltd., Prilaz baruna Filipovića 29, 10000 Zagreb, Croatia
3
Institute of Functional and Clinical Anatomy, University Medical Center of the Johannes Gutenberg University, Johann Joachim Becher Weg 13, D-55099 Mainz, Germany
4
Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, 30-1 Oyaguchi Kamicho, Itabashi-ku, Tokyo, 173-8610, Japan
*
Authors to whom correspondence should be addressed.
Polymers 2017, 9(7), 300; https://doi.org/10.3390/polym9070300
Received: 2 July 2017 / Revised: 16 July 2017 / Accepted: 20 July 2017 / Published: 22 July 2017
(This article belongs to the Special Issue Host-Guest Polymer Complexes)
The effect of polyphosphate (polyP) microparticles on wound healing was tested both in vitro and in a mice model in vivo. Two approaches were used: pure salts of polyphosphate, fabricated as amorphous microparticles (MPs, consisting of calcium and magnesium salts of polyP, “Ca–polyp-MPs” and “Mg–polyp-MPs”), and host–guest composite particles, prepared from amorphous collagen (host) and polyphosphate (guest), termed “col/polyp-MPs”. Animal experiments with polyP on healing of excisional wounds were performed using both normal mice and diabetic mice. After a healing period of 7 days “Ca–polyp-MP” significantly improved re-epithelialization in normal mice from 31% (control) to 72% (polyP microparticle-treated). Importantly, in diabetic mice, particularly the host–guest particles “col/polyp-MP”, increased the rate of re-epithelialization to ≈40% (control, 23%). In addition, those particles increased the expression of COL-I and COL-III as well as the expression the α-smooth muscle actin and the plasminogen activator inhibitor-1. We propose that “Ca–polyp-MPs”, and particularly the host–guest “col/polyp-MPs” are useful for topical treatment of wounds. View Full-Text
Keywords: polyphosphate; microparticles; delayed wound healing; collagen; PAI-1; re-epithelialization; diabetic mice polyphosphate; microparticles; delayed wound healing; collagen; PAI-1; re-epithelialization; diabetic mice
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MDPI and ACS Style

Müller, W.E.; Relkovic, D.; Ackermann, M.; Wang, S.; Neufurth, M.; Paravic Radicevic, A.; Ushijima, H.; Schröder, H.-C.; Wang, X. Enhancement of Wound Healing in Normal and Diabetic Mice by Topical Application of Amorphous Polyphosphate. Superior Effect of a Host–Guest Composite Material Composed of Collagen (Host) and Polyphosphate (Guest). Polymers 2017, 9, 300.

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