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Polymers 2017, 9(7), 253; https://doi.org/10.3390/polym9070253

Tailoring Drug Release Properties by Gradual Changes in the Particle Engineering of Polysaccharide Chitosan Based Powders

1
Laboratory of Pharmaceutical Technology and Biotechnology, Department of Pharmacy, Federal University of Rio Grande do Norte, UFRN, Gal. Gustavo Cordeiro de Farias, Petropolis, Natal 59072-570, RN, Brazil
2
Department of Pharmacy, Center of Health Sciences, Federal University of Pernambuco, Professor Moraes Rego 1235, Recife 50670-901, PE, Brazil
3
School of Pharmaceutical Sciences, Federal University of Amazonas, UFAM, General Rodrigo Octávio Jordão Ramos, 6200, South Sector, Manaus 69077-000, AM, Brazil
*
Author to whom correspondence should be addressed.
Academic Editor: George Papageorgiou
Received: 14 June 2017 / Revised: 22 June 2017 / Accepted: 24 June 2017 / Published: 29 June 2017
(This article belongs to the Special Issue Polymers from Renewable Resources)
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Abstract

Chitosan is a natural copolymer generally available in pharmaceutical and food powders associated with drugs, vitamins, and nutraceuticals. This study focused on monitoring the effect of the morphology and structural features of the chitosan particles for controlling the release profile of the active pharmaceutical ingredient (API) propranolol hydrochloride. Chitosan with distinct molecular mass (low and medium) were used in the formulations as crystalline and irregular particles from commercial raw material, or as spherical, uniform, and amorphous spray-dried particles. The API–copolymer interactions were assessed when adding the drug before (drug-loaded particles) or after the spray drying (only mixed with blank particles). The formulations were further compared with physical mixtures of the API with chitin and microcrystalline cellulose. The scanning electron microscopy (SEM) images, surface area, particle size measurements, X-ray diffraction (XRD) analysis and drug loading have supported the drug release behavior. The statistical analysis of experimental data demonstrated that it was possible to control the drug release behavior (immediate or slow drug release) from chitosan powders using different types of particles. View Full-Text
Keywords: polysaccharides; chitosan; microparticles; spray drying; structural properties; polymer characterization; drug release polysaccharides; chitosan; microparticles; spray drying; structural properties; polymer characterization; drug release
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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do Nascimento, E.G.; de Caland, L.B.; de Medeiros, A.S.; Fernandes-Pedrosa, M.F.; Soares-Sobrinho, J.L.; dos Santos, K.S.; da Silva-Júnior, A.A. Tailoring Drug Release Properties by Gradual Changes in the Particle Engineering of Polysaccharide Chitosan Based Powders. Polymers 2017, 9, 253.

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