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Polymers 2017, 9(8), 339;

Hyaluronic Acid Promotes the Osteogenesis of BMP-2 in an Absorbable Collagen Sponge

Department of Oral Implantology and Prosthetic Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), Universiteit van Amsterdam and Vrije Universiteit Amsterdam, Gustav Mahlerlaan 3004, 1081LA Amsterdam, Nord-Holland, The Netherlands
School of Stomatology, Zhejiang Chinese Medical University, Hangzhou 310053, China
Departments of Osteoporosis and Orthopaedic Surgery, Inselspital (DKF), University of Bern, Murtenstrasse 35, 3008 Bern, Switzerland
The authors contributed equally.
Author to whom correspondence should be addressed.
Received: 10 July 2017 / Revised: 24 July 2017 / Accepted: 31 July 2017 / Published: 4 August 2017
(This article belongs to the Special Issue Polymers from Renewable Resources)
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(1) Background: We tested the hypothesis that hyaluronic acid (HA) can significantly promote the osteogenic potential of BMP-2/ACS (absorbable collagen sponge), an efficacious product to heal large oral bone defects, thereby allowing its use at lower dosages and, thus, reducing its side-effects due to the unphysiologically-high doses of BMP-2; (2) Methods: In a subcutaneous bone induction model in rats, we first sorted out the optimal HA-polymer size and concentration with micro CT. Thereafter, we histomorphometrically quantified the effect of HA on new bone formation, total construct volume, and densities of blood vessels and macrophages in ACS with 5, 10, and 20 μg of BMP-2; (3) Results: The screening experiments revealed that the 100 µg/mL HA polymer of 48 kDa molecular weight could yield the highest new bone formation. Eighteen days post-surgery, HA could significantly enhance the total volume of newly-formed bone by approximately 100%, and also the total construct volume in the 10 μg BMP-2 group. HA could also significantly enhance the numerical area density of blood vessels in 5 μg BMP-2 and 10 μg BMP-2 groups. HA did not influence the numerical density of macrophages; and (4) Conclusions: An optimal combined administration of HA could significantly promote osteogenic and angiogenic activity of BMP-2/ACS, thus potentially minimizing its potential side-effects. View Full-Text
Keywords: hyaluronic acid; bone morphogenetic protein-2; absorbable collagen sponge; bone regeneration; angiogenesis hyaluronic acid; bone morphogenetic protein-2; absorbable collagen sponge; bone regeneration; angiogenesis

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Huang, H.; Feng, J.; Wismeijer, D.; Wu, G.; Hunziker, E.B. Hyaluronic Acid Promotes the Osteogenesis of BMP-2 in an Absorbable Collagen Sponge. Polymers 2017, 9, 339.

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