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Polymers 2017, 9(7), 249;

Sialic Acid-Targeted Biointerface Materials and Bio-Applications

State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, 122 Luoshi Road, Wuhan 430070, China
College of Mechanical Engineering, Jiangxi University of Technology, 115 Ziyang Road, Nanchang 330098, China
School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 122 Luoshi Road, Wuhan 430070, China
Authors to whom correspondence should be addressed.
Academic Editor: Raechelle D’Sa
Received: 6 June 2017 / Revised: 23 June 2017 / Accepted: 24 June 2017 / Published: 27 June 2017
(This article belongs to the Special Issue Advance of Polymers Applied to Biomedical Applications: Biointerface)
PDF [6234 KB, uploaded 27 June 2017]


Sialic acids (SAs) are typically found as terminal monosaccharides attached to cell surface glycoconjugates, which play crucial roles in various biological processes, and aberrant sialylation is closely associated with many diseases, particularly cancers. As SAs are overexpressed in tumor-associated glycoproteins, the recognition and specific binding of SA are crucial for monitoring, analyzing and controlling cancer cells, which would have a considerable impact on diagnostic and therapeutic application. However, both effective and selective recognition of SA on the cancer cell surface remains challenging. In recent years, SA-targeted biointerface materials have attracted great attention in various bio-applications, including cancer detection and imaging, drug delivery for cancer therapy and sialylated glycopeptide separation or enrichment. This review provides an overview of recent advances in SA-targeted biointerface materials and related bio-applications. View Full-Text
Keywords: sialic acids; biointerface materials; cancer detection and imaging; drug delivery sialic acids; biointerface materials; cancer detection and imaging; drug delivery

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Xiong, Y.; Li, M.; Lu, Q.; Qing, G.; Sun, T. Sialic Acid-Targeted Biointerface Materials and Bio-Applications. Polymers 2017, 9, 249.

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