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Open AccessArticle

Artificial Spores: Immunoprotective Nanocoating of Red Blood Cells with Supramolecular Ferric Ion-Tannic Acid Complex

1
Center for Cell-Encapsulation Research, Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea
2
Department of Chemistry and Chemistry Institute of Functional Materials, Pusan National University, Busan 46241, Korea
3
Department of Laboratory Medicine, College of Medicine, The Catholic University of Korea, St. Mary’s Hospital, Daejeon 34943, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Ruth Freitag
Polymers 2017, 9(4), 140; https://doi.org/10.3390/polym9040140
Received: 20 March 2017 / Revised: 12 April 2017 / Accepted: 12 April 2017 / Published: 13 April 2017
The blood-type-mismatch problem, in addition to shortage of blood donation, in blood transfusion has prompted the researchers to develop universal blood that does not require blood typing. In this work, the “cell-in-shell” (i.e., artificial spore) approach is utilized to shield the immune-provoking epitopes on the surface of red blood cells (RBCs). Individual RBCs are successfully coated with supramolecular metal-organic coordination complex of ferric ion (FeIII) and tannic acid (TA). The use of isotonic saline (0.85% NaCl) is found to be critical in the formation of stable, reasonably thick (20 nm) shells on RBCs without any aggregation and hemolysis. The formed “RBC-in-shell” structures maintain their original shapes, and effectively attenuate the antibody-mediated agglutination. Moreover, the oxygen-carrying capability of RBCs is not deteriorated after shell formation. This work suggests a simple but fast method for generating immune-camouflaged RBCs, which would contribute to the development of universal blood. View Full-Text
Keywords: artificial spores; cell-surface engineering; immunoprotection; nanocoating; red blood cells; supramolecular complex artificial spores; cell-surface engineering; immunoprotection; nanocoating; red blood cells; supramolecular complex
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MDPI and ACS Style

Park, T.; Kim, J.Y.; Cho, H.; Moon, H.C.; Kim, B.J.; Park, J.H.; Hong, D.; Park, J.; Choi, I.S. Artificial Spores: Immunoprotective Nanocoating of Red Blood Cells with Supramolecular Ferric Ion-Tannic Acid Complex. Polymers 2017, 9, 140.

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