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Polymers 2017, 9(4), 125;

A Gelated Colloidal Crystal Attached Lens for Noninvasive Continuous Monitoring of Tear Glucose

Department of Ophthalmology, EENT Hospital of Fudan University, Shanghai 200031, China
School of Environmental and Materials Engineering, College of Engineering, Shanghai Polytechnic University, Shanghai 201209, China
Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China
Authors to whom correspondence should be addressed.
Academic Editor: Po-Chih Yang
Received: 13 February 2017 / Revised: 15 March 2017 / Accepted: 23 March 2017 / Published: 28 March 2017
(This article belongs to the Special Issue Polymers for Chemosensing)
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Patients of diabetes mellitus urgently need noninvasive and continuous glucose monitoring in daily point-of-care. As the tear glucose concentration has a positive correlation with that in blood, the hydrogel colloidal crystal integrated into contact lens possesses promising potential for noninvasive monitoring of glucose in tears. This paper presents a new glucose-responsive sensor, which consists a crystalline colloidal array (CCA) embedded in hydrogel matrix, attached onto a rigid gas permeable (RGP) contact lens. This novel sensing lens is able to selectively diffract visible light, whose wavelength shifts between 567 and 468 nm according to the alternation of the glucose concentration between 0 and 50 mM and its visible color change between reddish yellow, green, and blue. The detection limit of responsive glucose concentration can be reduced to 0.05 mM. Its combination with a contact lens endows it with excellent biocompatibility and portability, which shows great possibility for it to push the development of glucose-detecting devices into new era. View Full-Text
Keywords: tear glucose; photonic crystal; contact lens; cytotoxicity; hydrogel; diffraction tear glucose; photonic crystal; contact lens; cytotoxicity; hydrogel; diffraction

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Ruan, J.-L.; Chen, C.; Shen, J.-H.; Zhao, X.-L.; Qian, S.-H.; Zhu, Z.-G. A Gelated Colloidal Crystal Attached Lens for Noninvasive Continuous Monitoring of Tear Glucose. Polymers 2017, 9, 125.

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