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Open AccessFeature PaperArticle

Thermo-Responsive Polyurethane Hydrogels Based on Poly(ε-caprolactone) Diol and Amphiphilic Polylactide-Poly(Ethylene Glycol) Block Copolymers

1
Institute of Polymer Science and Engineering, National Taiwan University, Taipei 10617, Taiwan
2
Institut Europeen des Membranes, UMR CNRS 5635, Universite de Montpellier, Place Eugene Bataillon, 34095 Montpellier Cedex 5, France
*
Author to whom correspondence should be addressed.
Academic Editor: Naozumi Teramoto
Polymers 2016, 8(7), 252; https://doi.org/10.3390/polym8070252
Received: 1 May 2016 / Revised: 26 June 2016 / Accepted: 29 June 2016 / Published: 5 July 2016
(This article belongs to the Special Issue Biodegradable Polymers)
Waterborne polyurethane (PU) based on poly(ε-caprolactone) (PCL) diol and an amphiphilic polylactide-poly(ethylene glycol) (PLA-PEG) diblock copolymer was synthesized. The molar ratio of PCL/PLA-PEG was 9:1 with different PLA chain lengths. The PU nanoparticles were characterized by dynamic light scattering (DLS), small angle X-ray scattering (SAXS) and rheological analysis. The water contact angle measurement, infrared spectroscopy, wide angle X-ray scattering (WAXS), thermal and mechanical analyses were conducted on PU films. Significant changes in physio-chemical properties were observed for PUs containing 10 mol % of amphiphilic blocks. The water contact angle was reduced to 12°–13°, and the degree of crystallinity was 5%–10%. The PU dispersions underwent sol-gel transition upon the temperature rise to 37 °C. The gelation time increased as the PLA chain length increased. In addition, the fractal dimension of each gel was close to that of a percolation cluster. Moreover, PU4 with a solid content of 26% could support the proliferation of human mesenchymal stem cells (hMSCs). Therefore, thermo-responsive hydrogels with tunable properties are promising injectable materials for cell or drug delivery. View Full-Text
Keywords: waterborne polyurethane; poly(ε-caprolactone); polylactide–poly(ethylene glycol); small angle X-ray scattering (SAXS); hydrogel waterborne polyurethane; poly(ε-caprolactone); polylactide–poly(ethylene glycol); small angle X-ray scattering (SAXS); hydrogel
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MDPI and ACS Style

Hsu, S.-H.; Chen, C.-W.; Hung, K.-C.; Tsai, Y.-C.; Li, S. Thermo-Responsive Polyurethane Hydrogels Based on Poly(ε-caprolactone) Diol and Amphiphilic Polylactide-Poly(Ethylene Glycol) Block Copolymers. Polymers 2016, 8, 252.

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