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Polymers 2016, 8(6), 214;

Functionalized Polymers for Enhance Oral Bioavailability of Sensitive Molecules

Departamento de Ingeniería Química e Investigación, Instituto Tecnológico de Toluca, Apartado Postal 890, 52149 Metepec, MEX, Mexico
Departamento de Ingeniería Química y Tecnología de Medio Ambiente, Universidad de Oviedo, Oviedo, 33006 Asturias, Spain
Author to whom correspondence should be addressed.
Academic Editor: Jianxun Ding
Received: 16 March 2016 / Revised: 30 April 2016 / Accepted: 11 May 2016 / Published: 2 June 2016
(This article belongs to the Special Issue Functional Polymers for Medical Applications)
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Currently, many sensitive molecules have been studied for effective oral administration. These substances are biologically active compounds that mainly suffer early degradation in the gastrointestinal tract (GIT) and physicochemical instability, inactivation and poor solubility and permeability. The sensibility of the biomolecules has limited their oral administration in the body and today is an important research topic to achieve desired effects in medicine field. Under this perspective, various enhancement approaches have been studied as alternatives to increase their oral bioavailability. Some of these strategies include functionalized polymers to provide specific useful benefits as protection to the intestinal tract by preventing its degradation by stomach enzymes, to increase their absorption, permeability, stability, and to make a proper release in the GIT. Due to specific chemical groups, shapes and sizes, morphologies, mechanical properties, and degradation, recent advances in functionalized polymers have opened the door to great possibilities to improve the physicochemical characteristics of these biopharmaceuticals. Today, many biomolecules are found in basic studies, preclinical steps, and others are late stage clinical development. This review summarizes the contribution of functionalized polymers to enhance oral bioavailability of sensitive molecules and their application status in medicine for different diseases. Future trends of these polymers and their possible uses to achieve different formulation goals for oral delivery are also covered in this manuscript. View Full-Text
Keywords: functionalized polymers; enhance strategies; biopharmaceuticals; oral bioavailability functionalized polymers; enhance strategies; biopharmaceuticals; oral bioavailability

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Pérez, Y.A.; Urista, C.M.; Martínez, J.I.; Nava, M.D.C.D.; Rodríguez, F.A.R. Functionalized Polymers for Enhance Oral Bioavailability of Sensitive Molecules. Polymers 2016, 8, 214.

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