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Open AccessArticle

Keratin/Polyvinyl Alcohol Blend Films Cross-Linked by Dialdehyde Starch and Their Potential Application for Drug Release

1
School of Materials Science and Engineering, Northwestern Polytechnical University, Xian 710072, Shanxi, China
2
Green Chemical Engineering Institute, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, Guangdong, China
3
Guangzhou Vocational College of Science and Technology, Guangzhou 510550, Guangdong, China
4
School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton BN2 4GJ, UK
*
Author to whom correspondence should be addressed.
Academic Editors: João F. Mano and Ernst Wagner
Polymers 2015, 7(3), 580-591; https://doi.org/10.3390/polym7030580
Received: 20 December 2014 / Revised: 6 February 2015 / Accepted: 15 February 2015 / Published: 23 March 2015
(This article belongs to the Collection Polysaccharides)
Feather keratin (FK) extracted from feathers represents a valuable source of biodegradable and biocompatible polymer. The aim of this study was the development and characterization of blended films based on FK and polyvinyl alcohol (PVA) cross-linked by dialdehyde starch (DAS) for a potential drug release application. The compatibility of FK/PVA was improved when cross-linked by DAS: the relative crystallinity of the PVA/FK film slightly decreased, and the enthalpy value for the melting peak decreased by about 50% for the cross-linked films. The total soluble mass of all blend films in water was below 35% at 37 °C, indicating a good stability of the films in water. The results of the Rhodamine B dye (as a model drug) release tests showed that the release rates decreased with increasing DAS content. DAS-induced cross-linking improves several important properties of the FK/PVA films, such as the compactness, the compatibility, and the stability in water. These improvements offer the potential to expand the application of FK films in the biomaterial field. View Full-Text
Keywords: feather keratin; PVA; dialdehyde starch; degradable film; eco-friendly material feather keratin; PVA; dialdehyde starch; degradable film; eco-friendly material
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MDPI and ACS Style

Dou, Y.; Zhang, B.; He, M.; Yin, G.; Cui, Y.; Savina, I.N. Keratin/Polyvinyl Alcohol Blend Films Cross-Linked by Dialdehyde Starch and Their Potential Application for Drug Release. Polymers 2015, 7, 580-591.

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