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Open AccessArticle

Effects of RAFT Agent on the Selective Approach of Molecularly Imprinted Polymers

1
Department of Chemistry, Faculty of Science, University of Malaya, Lembah Pantai, 50603 Kuala Lumpur, Malaysia
2
Department of Science and Mathematics, Faculty of Science, Technology and Human Development, University of Tun Hussein Onn Malaysia, Parit Raja, 86400 Johor, Malaysia
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Philipp Vana
Polymers 2015, 7(3), 484-503; https://doi.org/10.3390/polym7030484
Received: 12 July 2014 / Revised: 16 February 2015 / Accepted: 2 March 2015 / Published: 6 March 2015
Two types of reversible addition-fragmentation chain transfer molecularly imprinted polymers (RAFT-MIPs) were synthesized using different monomers, which were methacrylic acid functionalized β-cyclodextrin (MAA-β-CD) and 2-hydroxyethyl methacrylate functionalized β-cyclodextrin (HEMA-β-CD), via reversible addition-fragmentation chain transfer (RAFT) polymerization, and were represented as RAFT-MIP(MAA-β-CD) and RAFT-MIP(HEMA-β-CD), respectively. Both RAFT-MIPs were systematically characterized using Fourier Transform Infrared Spectroscopy (FTIR), Field Emission Scanning Electron Microscopy (FESEM), Brunauer-Emmett-Teller (BET), and rebinding experimental study. The results were compared with MIPs synthesized via the traditional radical polymerization (TRP) process, and were represented as MIP(MAA-β-CD) and MIP(HEMA-β-CD). Morphology results show that RAFT-MIP(MAA-β-CD) has a slightly spherical feature with a sponge-like form, while RAFT-MIP(HEMA-β-CD) has a compact surface. BET results show that the surface area of RAFT-MIP(MAA-β-CD) is higher than MIP(MAA-β-CD), while the RAFT-MIP(HEMA-β-CD) surface area is lower than that of MIP(HEMA-β-CD). Rebinding experiments indicate that the RAFT agent increased the binding capacity of RAFT-MIP(MAA-β-CD), but not of RAFT-MIP(HEMA-β-CD), which proves that a RAFT agent does not always improve the recognition affinity and selective adsorption of MIPs. The usability of a RAFT agent depends on the monomer used to generate potential MIPs. View Full-Text
Keywords: molecularly imprinted polymer; methacrylic acid functionalized β-cyclodextrin; 2-hydroxyethyl methacrylate functionalized β-cyclodextrin; RAFT agent molecularly imprinted polymer; methacrylic acid functionalized β-cyclodextrin; 2-hydroxyethyl methacrylate functionalized β-cyclodextrin; RAFT agent
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Asman, S.; Mohamad, S.; Sarih, N.M. Effects of RAFT Agent on the Selective Approach of Molecularly Imprinted Polymers. Polymers 2015, 7, 484-503.

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