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Polymers 2013, 5(3), 1102-1114;

Hybrid, Nanoscale Phospholipid/Block Copolymer Vesicles

Centre for Biomimetic Sensor Science, School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Drive, 637553, Singapore
Institute of Materials Research and Engineering, A*STAR (Agency for Science, Technology and Research), 3 Research link, 117602, Singapore
Departments of Biomedical Engineering, Chemical Engineering and Materials Science, University of California, Davis, CA, 95616, USA
Authors to whom correspondence should be addressed.
Received: 1 July 2013 / Revised: 5 August 2013 / Accepted: 29 August 2013 / Published: 6 September 2013
(This article belongs to the Special Issue Supramolecular Chemistry and Self-Assembly)
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Hybrid phospholipid/block copolymer vesicles, in which the polymeric membrane is blended with phospholipids, display interesting self-assembly behavior, incorporating the robustness and chemical versatility of polymersomes with the softness and biocompatibility of liposomes. Such structures can be conveniently characterized by preparing giant unilamellar vesicles (GUVs) via electroformation. Here, we are interested in exploring the self-assembly and properties of the analogous nanoscale hybrid vesicles (ca. 100 nm in diameter) of the same composition prepared by film-hydration and extrusion. We show that the self-assembly and content-release behavior of nanoscale polybutadiene-b-poly(ethylene oxide) (PB-PEO)/1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylcholine (POPC) hybrid phospholipid/block copolymer vesicles can be tuned by the mixing ratio of the amphiphiles. In brief, these hybrids may provide alternative tools for drug delivery purposes and molecular imaging/sensing applications and clearly open up new avenues for further investigation. View Full-Text
Keywords: polymersomes; hybrid vesicles; self-assembly; drug-delivery; soft matter polymersomes; hybrid vesicles; self-assembly; drug-delivery; soft matter

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Lim, S.K.; De Hoog, H.-P.; Parikh, A.N.; Nallani, M.; Liedberg, B. Hybrid, Nanoscale Phospholipid/Block Copolymer Vesicles. Polymers 2013, 5, 1102-1114.

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