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Polymers 2010, 2(4), 407-417;

Synthesis of Propargyl-Terminated Heterobifunctional Poly(ethylene glycol)

Department of Textile Sciences, Faculty of Human Ecology, University of Manitoba, Winnipeg, MB R3T 2N2, Canada
Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, MB R3T 2N2, Canada
Author to whom correspondence should be addressed.
Received: 22 September 2010 / Revised: 4 October 2010 / Accepted: 8 October 2010 / Published: 13 October 2010
(This article belongs to the Special Issue Biofunctional Polymers for Medical Applications)
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Novel propargyl-ended heterobifunctional poly(ethylene glycol) (PEG) derivatives with hydroxyl, carboxyl, mercapto or hydrazide end groups were synthesized with simplicity yet high efficiency. PEG (Mw = 3500 Da) with an α-hydroxyl group and an ω-carboxyl was used as the starting polymer. The carboxyl group of the bifunctional PEG was modified into a propargyl, then carboxyl, mercapto or hydrazide groups were introduced to the other end of the bifunctional PEG by modifying the bifunctional PEG’s hydroxyl group with succinic anhydride, cysteamide or tert-butyl carbazate, respectively. This method can be useful to the development of PEG-based bioconjugates for a variety of biomedical applications. View Full-Text
Keywords: heterobifunctional; poly(ethylene glycol); “click” chemistry heterobifunctional; poly(ethylene glycol); “click” chemistry

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Lu, C.; Zhong, W. Synthesis of Propargyl-Terminated Heterobifunctional Poly(ethylene glycol). Polymers 2010, 2, 407-417.

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