Polyethylenimine-Functionalized Nanofiber Nonwovens Electrospun from Cotton Cellulose for Wound Dressing with High Drug Loading and Sustained Release Properties
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials
2.2. Preparation of Cellulose Solution
2.3. Preparation of Electrospun Cellulose Nonwoven
2.4. Preparation of Cellulose-NH2 Membrane
2.5. Preparation of Cellulose-PEI Membrane
2.6. Material Characterization
2.7. Standard Curve Measurement
2.8. Drug Adsorption
2.9. Drug Release Study
3. Results and Discussion
3.1. Fabrication of Cellulose-PEI Nonwoven Membranes
3.2. Morphological and Structural Characterization of Cellulose-PEI
3.3. Drug Adsorption Studies
3.3.1. The Effect of pH on the Drug Adsorption Capacity
3.3.2. The Effect of Drug Concentration on Adsorption Capacity
3.4. Drug Release Study
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Langmuir Model | Freundlich Model | |
---|---|---|
qm (mg/g) | 265.25 | -- |
KL (L/mg) | 0.015 | -- |
n | -- | 2.39 |
KF (L/mg) | -- | 13.47 |
R2 | 0.8580 | 0.9681 |
Zero-Order Model | First-Order Model | Higuchi Model | |
---|---|---|---|
k R2 | 0.1223 0.7233 | 1.7861 0.9656 | 0.3635 0.2228 |
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Wang, Q.; Li, M.; Zheng, Z.; Niu, Y.; Xue, X.; Ao, C.; Zhang, W.; Lu, C. Polyethylenimine-Functionalized Nanofiber Nonwovens Electrospun from Cotton Cellulose for Wound Dressing with High Drug Loading and Sustained Release Properties. Polymers 2022, 14, 1748. https://doi.org/10.3390/polym14091748
Wang Q, Li M, Zheng Z, Niu Y, Xue X, Ao C, Zhang W, Lu C. Polyethylenimine-Functionalized Nanofiber Nonwovens Electrospun from Cotton Cellulose for Wound Dressing with High Drug Loading and Sustained Release Properties. Polymers. 2022; 14(9):1748. https://doi.org/10.3390/polym14091748
Chicago/Turabian StyleWang, Qunhao, Mei Li, Zhuo Zheng, Yan Niu, Xiaolin Xue, Chenghong Ao, Wei Zhang, and Canhui Lu. 2022. "Polyethylenimine-Functionalized Nanofiber Nonwovens Electrospun from Cotton Cellulose for Wound Dressing with High Drug Loading and Sustained Release Properties" Polymers 14, no. 9: 1748. https://doi.org/10.3390/polym14091748