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Article

Iodo Silanes as Superior Substrates for the Solid Phase Synthesis of Molecularly Imprinted Polymer Nanoparticles

1
Department of Chemistry, Molecular Sciences Research Hub, White City Campus, Imperial College London, London W12 0BZ, UK
2
School of Chemistry, College of Science and Engineering, University of Leicester, Leicester LE1 7RH, UK
3
Department of Surgery and Cancer, Hammersmith Campus, Imperial College, London W12 0NN, UK
*
Author to whom correspondence should be addressed.
Academic Editor: Michał Cegłowski
Polymers 2022, 14(8), 1595; https://doi.org/10.3390/polym14081595
Received: 23 March 2022 / Revised: 11 April 2022 / Accepted: 12 April 2022 / Published: 14 April 2022
(This article belongs to the Special Issue Frontier in Molecularly Imprinted Polymers)
Current state-of-the-art techniques for the solid phase synthesis of molecularly imprinted polymer (MIP) nanoparticles typically rely on amino silanes for the immobilisation of template molecules prior to polymerisation. An investigation into commonly used amino silanes identified a number of problematic side reactions which negatively affect the purity and affinity of these polymers. Iodo silanes are presented as a superior alternative in a case study describing the synthesis of MIPs against epitopes of a common cancer biomarker, epidermal growth factor receptor (EGFR). The proposed iodo silane outperformed the amino silane by all metrics tested, showing high purity and specificity, and nanomolar affinity for the target peptide. View Full-Text
Keywords: molecularly imprinted polymers; solid phase synthesis; epidermal growth factor receptor molecularly imprinted polymers; solid phase synthesis; epidermal growth factor receptor
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MDPI and ACS Style

Piletsky, S.S.; Garcia Cruz, A.; Piletska, E.; Piletsky, S.A.; Aboagye, E.O.; Spivey, A.C. Iodo Silanes as Superior Substrates for the Solid Phase Synthesis of Molecularly Imprinted Polymer Nanoparticles. Polymers 2022, 14, 1595. https://doi.org/10.3390/polym14081595

AMA Style

Piletsky SS, Garcia Cruz A, Piletska E, Piletsky SA, Aboagye EO, Spivey AC. Iodo Silanes as Superior Substrates for the Solid Phase Synthesis of Molecularly Imprinted Polymer Nanoparticles. Polymers. 2022; 14(8):1595. https://doi.org/10.3390/polym14081595

Chicago/Turabian Style

Piletsky, Stanislav S., Alvaro Garcia Cruz, Elena Piletska, Sergey A. Piletsky, Eric O. Aboagye, and Alan C. Spivey. 2022. "Iodo Silanes as Superior Substrates for the Solid Phase Synthesis of Molecularly Imprinted Polymer Nanoparticles" Polymers 14, no. 8: 1595. https://doi.org/10.3390/polym14081595

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