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Polymers
Volume 14
Issue 3
10.3390/polym14030391
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Article

Cross-Linked Gelatine by Modified Dextran as a Potential Bioink Prepared by a Simple and Non-Toxic Process

by
Lenka Musilová
1,2,
Eva Achbergerová
3,
Lenka Vítková
1,
Roman Kolařík
2,
Martina Martínková
2,
Antonín Minařík
1,2,
Aleš Mráček
1,2,*,
Petr Humpolíček
1,2 and
Jiří Pecha
3
1
Department of Physics and Materials Engineering, Faculty of Technology, Tomas Bata University in Zlin, Vavreckova 275, 760 01 Zlín, Czech Republic
2
Centre of Polymer Systems, Tomas Bata University in Zlín, tř. Tomáše Bati 5678, 760 01 Zlín, Czech Republic
3
CEBIA-Tech, Faculty of Applied Informatics, Tomas Bata University in Zlín, Nad Stráněmi 4511, 760 05 Zlín, Czech Republic
*
Author to whom correspondence should be addressed.
Polymers 2022, 14(3), 391; https://doi.org/10.3390/polym14030391
Submission received: 20 December 2021 / Revised: 10 January 2022 / Accepted: 14 January 2022 / Published: 19 January 2022
(This article belongs to the Special Issue Polymers and Biopolymers for Tissue Engineering)
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Abstract

Essential features of well-designed materials intended for 3D bioprinting via microextrusion are the appropriate rheological behavior and cell-friendly environment. Despite the rapid development, few materials are utilizable as bioinks. The aim of our work was to design a novel cytocompatible material facilitating extrusion-based 3D printing while maintaining a relatively simple and straightforward preparation process without the need for harsh chemicals or radiation. Specifically, hydrogels were prepared from gelatines coming from three sources—bovine, rabbit, and chicken—cross-linked by dextran polyaldehyde. The influence of dextran concentration on the properties of hydrogels was studied. Rheological measurements not only confirmed the strong shear-thinning behavior of prepared inks but were also used for capturing cross-linking reaction kinetics and demonstrated quick achievement of gelation point (in most cases < 3 min). Their viscoelastic properties allowed satisfactory extrusion, forming a self-supported multi-layered uniformly porous structure. All gelatin-based hydrogels were non-cytototoxic. Homogeneous cells distribution within the printed scaffold was confirmed by fluorescence confocal microscopy. In addition, no disruption of cells structure was observed. The results demonstrate the great potential of the presented hydrogels for applications related to 3D bioprinting.
Keywords: gelatine-dextran; hydrogel; 3D printing, microextrusion; rheology; cell distribution gelatine-dextran; hydrogel; 3D printing, microextrusion; rheology; cell distribution
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MDPI and ACS Style

Musilová, L.; Achbergerová, E.; Vítková, L.; Kolařík, R.; Martínková, M.; Minařík, A.; Mráček, A.; Humpolíček, P.; Pecha, J. Cross-Linked Gelatine by Modified Dextran as a Potential Bioink Prepared by a Simple and Non-Toxic Process. Polymers 2022, 14, 391. https://doi.org/10.3390/polym14030391

AMA Style

Musilová L, Achbergerová E, Vítková L, Kolařík R, Martínková M, Minařík A, Mráček A, Humpolíček P, Pecha J. Cross-Linked Gelatine by Modified Dextran as a Potential Bioink Prepared by a Simple and Non-Toxic Process. Polymers. 2022; 14(3):391. https://doi.org/10.3390/polym14030391

Chicago/Turabian Style

Musilová, Lenka, Eva Achbergerová, Lenka Vítková, Roman Kolařík, Martina Martínková, Antonín Minařík, Aleš Mráček, Petr Humpolíček, and Jiří Pecha. 2022. "Cross-Linked Gelatine by Modified Dextran as a Potential Bioink Prepared by a Simple and Non-Toxic Process" Polymers 14, no. 3: 391. https://doi.org/10.3390/polym14030391

APA Style

Musilová, L., Achbergerová, E., Vítková, L., Kolařík, R., Martínková, M., Minařík, A., Mráček, A., Humpolíček, P., & Pecha, J. (2022). Cross-Linked Gelatine by Modified Dextran as a Potential Bioink Prepared by a Simple and Non-Toxic Process. Polymers, 14(3), 391. https://doi.org/10.3390/polym14030391

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