Electrospinning Drug-Loaded Alginate-Based Nanofibers towards Developing a Drug Release Rate Catalog
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials
2.2. Creation of Alginate-Based Nanofibers
2.2.1. Preparation of Alginate and PVA (Alg-PVA) Electrospinning Solution
2.2.2. Preparation of Alginate and Agarose (Alg-Ag) Electrospinning Solution
2.2.3. Preparation of Cipro-Loaded Alginate-Based Electrospinning Solution
2.3. Electrospinning Alginate-Based Nanofibers
2.4. Analysis of Nanofibers
2.5. Release Studies of Drug-Loaded Alginate-Based Nanofibers
3. Results
3.1. Alg-PVA Nanofibers
3.2. Alg-Ag and Alginate, PVA, and Agarose (Alg-PVA-Ag) Nanofibers
3.3. Cipro-Loaded Alg-PVA Nanofibers
3.4. Release Studies on Drug-Loaded Alg-PVA Nanofibers
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Polymer Ratio | Polymer Formulation | Cipro Percentage (w/v) | Rate (μL/min) | Height (mm) | Voltage (kV) | Volume Dispersed (mL) | Average Cipro Release 1 (mM) |
---|---|---|---|---|---|---|---|
3:7 | 2.5% Alg:10% PVA | 0 | 9.8 | 100 | 16 | 1 | 0 |
3:7 | 2.5% Alg:10% PVA | 3.0 | 9.8 | 100 | 16 | 1 | 0.134 |
3:7 | 2.5% Alg:10% PVA | 3.5 | 9.8 | 100 | 16 | 1 | 0.920 |
3:7 | 2.5% Alg:10% PVA | 5 | 9.8 | 100 | 16 | 1 | 0.924 |
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Penton, K.E.; Kinler, Z.; Davis, A.; Spiva, J.A.; Hamilton, S.K. Electrospinning Drug-Loaded Alginate-Based Nanofibers towards Developing a Drug Release Rate Catalog. Polymers 2022, 14, 2773. https://doi.org/10.3390/polym14142773
Penton KE, Kinler Z, Davis A, Spiva JA, Hamilton SK. Electrospinning Drug-Loaded Alginate-Based Nanofibers towards Developing a Drug Release Rate Catalog. Polymers. 2022; 14(14):2773. https://doi.org/10.3390/polym14142773
Chicago/Turabian StylePenton, Kathryn E., Zachary Kinler, Amber Davis, Joshua A. Spiva, and Sharon K. Hamilton. 2022. "Electrospinning Drug-Loaded Alginate-Based Nanofibers towards Developing a Drug Release Rate Catalog" Polymers 14, no. 14: 2773. https://doi.org/10.3390/polym14142773