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Article

Visible Light-Curable Chitosan Ink for Extrusion-Based and Vat Polymerization-Based 3D Bioprintings

Division of Chemical Engineering, Department of Materials Engineering Science, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama-cho, Toyonaka, Osaka 560-8531, Japan
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Academic Editors: Vincenzo La Carrubba and Francesco Lopresti
Polymers 2021, 13(9), 1382; https://doi.org/10.3390/polym13091382
Received: 31 March 2021 / Revised: 17 April 2021 / Accepted: 20 April 2021 / Published: 23 April 2021
Three-dimensional bioprinting has attracted much attention for biomedical applications, including wound dressing and tissue regeneration. The development of functional and easy-to-handle inks is expected to expand the applications of this technology. In this study, aqueous solutions of chitosan derivatives containing sodium persulfate (SPS) and Tris(2,2′-bipyridyl) ruthenium(II) chloride (Ru(bpy)3) were applied as inks for both extrusion-based and vat polymerization-based bioprinting. In both the printing systems, the curation of ink was caused by visible light irradiation. The gelation time of the solution and the mechanical properties of the resultant hydrogels could be altered by changing the concentrations of SPS and Ru(bpy)3. The 3D hydrogel constructs with a good shape fidelity were obtained from the chitosan inks with a composition that formed gel within 10 s. In addition, we confirmed that the chitosan hydrogels have biodegradability and antimicrobial activity. These results demonstrate the significant potential of using the visible light-curable inks containing a chitosan derivative for extrusion and vat polymerization-based bioprinting toward biomedical applications. View Full-Text
Keywords: bioprinting; extrusion-based printing; vat polymerization-based printing; chitosan; photocurable material bioprinting; extrusion-based printing; vat polymerization-based printing; chitosan; photocurable material
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MDPI and ACS Style

Hidaka, M.; Kojima, M.; Nakahata, M.; Sakai, S. Visible Light-Curable Chitosan Ink for Extrusion-Based and Vat Polymerization-Based 3D Bioprintings. Polymers 2021, 13, 1382. https://doi.org/10.3390/polym13091382

AMA Style

Hidaka M, Kojima M, Nakahata M, Sakai S. Visible Light-Curable Chitosan Ink for Extrusion-Based and Vat Polymerization-Based 3D Bioprintings. Polymers. 2021; 13(9):1382. https://doi.org/10.3390/polym13091382

Chicago/Turabian Style

Hidaka, Mitsuyuki, Masaru Kojima, Masaki Nakahata, and Shinji Sakai. 2021. "Visible Light-Curable Chitosan Ink for Extrusion-Based and Vat Polymerization-Based 3D Bioprintings" Polymers 13, no. 9: 1382. https://doi.org/10.3390/polym13091382

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