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Article

Hyaluronic Acid Treatment Improves Healing of the Tenorrhaphy Site by Suppressing Adhesions through Extracellular Matrix Remodeling in a Rat Model

1
Department of Plastic and Reconstructive Surgery, Soonchunhyang University College of Medicine, Soonchunhyang University Bucheon Hospital, Bucheon 14584, Korea
2
Department of Integrated Biomedical Science, Soonchunhyang University, Asan-si 31538, Korea
3
Soonchunhyang Institute of Medi-Bio Science (SIMS), Soonchunhyang University, Cheonan-si 31151, Korea
*
Authors to whom correspondence should be addressed.
Academic Editor: Young-Sam Cho
Polymers 2021, 13(6), 928; https://doi.org/10.3390/polym13060928
Received: 4 March 2021 / Revised: 14 March 2021 / Accepted: 15 March 2021 / Published: 17 March 2021
(This article belongs to the Special Issue Polymeric Materials as Scaffolds for Tissue Engineering)
Due to the limited supply of vessels and nerves, acute or chronic tendon injuries often result in significant and persistent complications, such as pain and sprains, as well as the loss of joint functions. Among these complications, tendon adhesions within the surrounding soft tissue have been shown to significantly impair the range of motion. In this study, to elucidate the effects of a hyaluronic acid (HA) injection at the site of tenorrhaphy on tendon adhesion formation, we used a full transection model of a rat’s Achilles tendon to investigate the anti-adhesive function of HA. Our initial findings showed that significantly lower adhesion scores were observed in the HA-treated experimental group than in the normal saline-treated control group, as determined by macroscopic and histological evaluations. Hematoxylin and eosin, as well as picrosirius red staining, showed denser and irregular collagen fibers, with the larger number of infiltrating inflammatory cells in the control group indicating severe adhesion formation. Furthermore, we observed that the expression of tendon adhesion markers in operated tendon tissue, such as collagen type I, transforming growth factor-β1, and plasminogen activator inhibitor-1, was suppressed at both the gene and protein levels following HA treatment. These results suggest that HA injections could reduce tendon adhesion formation by significantly ameliorating inflammatory-associated reactions. View Full-Text
Keywords: tendon injury; tendon adhesion; hyaluronic acid; transforming growth factor-β1; plasminogen activator inhibitor-1 tendon injury; tendon adhesion; hyaluronic acid; transforming growth factor-β1; plasminogen activator inhibitor-1
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MDPI and ACS Style

Ahn, K.H.; Park, E.S.; Choi, C.Y.; Cha, H.G.; Hwang, Y.; Nam, S.M. Hyaluronic Acid Treatment Improves Healing of the Tenorrhaphy Site by Suppressing Adhesions through Extracellular Matrix Remodeling in a Rat Model. Polymers 2021, 13, 928. https://doi.org/10.3390/polym13060928

AMA Style

Ahn KH, Park ES, Choi CY, Cha HG, Hwang Y, Nam SM. Hyaluronic Acid Treatment Improves Healing of the Tenorrhaphy Site by Suppressing Adhesions through Extracellular Matrix Remodeling in a Rat Model. Polymers. 2021; 13(6):928. https://doi.org/10.3390/polym13060928

Chicago/Turabian Style

Ahn, Kwang H., Eun S. Park, Chang Y. Choi, Han G. Cha, Yongsung Hwang, and Seung M. Nam. 2021. "Hyaluronic Acid Treatment Improves Healing of the Tenorrhaphy Site by Suppressing Adhesions through Extracellular Matrix Remodeling in a Rat Model" Polymers 13, no. 6: 928. https://doi.org/10.3390/polym13060928

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