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Article

The Influence of Hydrophobic Blocks of PEO-Containing Copolymers on Glyceryl Monooleate Lyotropic Liquid Crystalline Nanoparticles for Drug Delivery

1
Centre of Polymer and Carbon Materials, Polish Academy of Sciences, 34 ul. M. Curie-Skłodowskiej, 41-819 Zabrze, Poland
2
Section of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimioupolis Zografou, 15771 Athens, Greece
3
Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, 11635 Athens, Greece
*
Author to whom correspondence should be addressed.
Academic Editor: Vitaliy Khutoryanskiy
Polymers 2021, 13(16), 2607; https://doi.org/10.3390/polym13162607
Received: 1 July 2021 / Revised: 29 July 2021 / Accepted: 2 August 2021 / Published: 5 August 2021
The investigation of properties of amphiphilic block copolymers as stabilizers for non-lamellar lyotropic liquid crystalline nanoparticles represents a fundamental issue for the formation, stability and upgraded functionality of these nanosystems. The aim of this work is to use amphiphilic block copolymers, not studied before, as stabilizers of glyceryl monooleate 1-(cis-9-octadecenoyl)-rac-glycerol (GMO) colloidal dispersions. Nanosystems were prepared with the use of poly(ethylene oxide)-b-poly(lactic acid) (PEO-b-PLA) and poly(ethylene oxide)-b-poly(5-methyl-5-ethyloxycarbonyl-1,3-dioxan-2-one) (PEO-b-PMEC) block copolymers. Different GMO:polymer molar ratios lead to formulation of nanoparticles with different size and internal organization, depending on the type of hydrophobic block. Resveratrol was loaded into the nanosystems as a model hydrophobic drug. The physicochemical and morphological characteristics of the prepared nanosystems were investigated by dynamic light scattering (DLS), cryogenic transmission electron microscopy (cryo-TEM), fast Fourier transform (FFT) analysis and X-ray diffraction (XRD). The studies allowed the description of the lyotropic liquid crystalline nanoparticles and evaluation of impact of copolymer composition on these nanosystems. The structures formed in GMO:block copolymer colloidal dispersions were compared with those discussed previously. The investigations broaden the toolbox of polymeric stabilizers for the development of this type of hybrid polymer/lipid nanostructures. View Full-Text
Keywords: amphiphilic block copolymers; lipidic lyotropic liquid crystals; cryogenic transmission electron microscopy; fast Fourier transform; dynamic light scattering; X-ray diffraction; resveratrol; lipid/polymer carriers amphiphilic block copolymers; lipidic lyotropic liquid crystals; cryogenic transmission electron microscopy; fast Fourier transform; dynamic light scattering; X-ray diffraction; resveratrol; lipid/polymer carriers
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MDPI and ACS Style

Forys, A.; Chountoulesi, M.; Mendrek, B.; Konieczny, T.; Sentoukas, T.; Godzierz, M.; Kordyka, A.; Demetzos, C.; Pispas, S.; Trzebicka, B. The Influence of Hydrophobic Blocks of PEO-Containing Copolymers on Glyceryl Monooleate Lyotropic Liquid Crystalline Nanoparticles for Drug Delivery. Polymers 2021, 13, 2607. https://doi.org/10.3390/polym13162607

AMA Style

Forys A, Chountoulesi M, Mendrek B, Konieczny T, Sentoukas T, Godzierz M, Kordyka A, Demetzos C, Pispas S, Trzebicka B. The Influence of Hydrophobic Blocks of PEO-Containing Copolymers on Glyceryl Monooleate Lyotropic Liquid Crystalline Nanoparticles for Drug Delivery. Polymers. 2021; 13(16):2607. https://doi.org/10.3390/polym13162607

Chicago/Turabian Style

Forys, Aleksander, Maria Chountoulesi, Barbara Mendrek, Tomasz Konieczny, Theodore Sentoukas, Marcin Godzierz, Aleksandra Kordyka, Costas Demetzos, Stergios Pispas, and Barbara Trzebicka. 2021. "The Influence of Hydrophobic Blocks of PEO-Containing Copolymers on Glyceryl Monooleate Lyotropic Liquid Crystalline Nanoparticles for Drug Delivery" Polymers 13, no. 16: 2607. https://doi.org/10.3390/polym13162607

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