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Review

How to Sterilize Polylactic Acid Based Medical Devices?

1
New Materials Group, Campus Lagoas-Marcosende, CINTECX, Universidade de Vigo, 36310 Vigo, Spain
2
Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, 36213 Vigo, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Vitaliy Khutoryanskiy
Polymers 2021, 13(13), 2115; https://doi.org/10.3390/polym13132115
Received: 19 May 2021 / Revised: 18 June 2021 / Accepted: 23 June 2021 / Published: 28 June 2021
(This article belongs to the Section Polymer Applications)
How sterilization techniques accurately affect the properties of biopolymers continues to be an issue of discussion in the field of biomedical engineering, particularly now with the development of 3D-printed devices. One of the most widely used biopolymers in the manufacture of biomedical devices is the polylactic acid (PLA). Despite the large number of studies found in the literature on PLA devices, relatively few papers focus on the effects of sterilization treatments on its properties. It is well documented in the literature that conventional sterilization techniques, such as heat, gamma irradiation and ethylene oxide, can induced damages, alterations or toxic products release, due to the thermal and hydrolytical sensitivity of PLA. The purposes of this paper are, therefore, to review the published data on the most common techniques used to sterilize PLA medical devices and to analyse how they are affecting their physicochemical and biocompatible properties. Emerging and alternative sterilization methods for sensitive biomaterials are also presented. View Full-Text
Keywords: medical devices; polymers; polylactic acid (PLA); 3D printing; sterilization; supercritical CO2; gamma irradiation; steam; ethylene oxide medical devices; polymers; polylactic acid (PLA); 3D printing; sterilization; supercritical CO2; gamma irradiation; steam; ethylene oxide
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MDPI and ACS Style

Pérez Davila, S.; González Rodríguez, L.; Chiussi, S.; Serra, J.; González, P. How to Sterilize Polylactic Acid Based Medical Devices? Polymers 2021, 13, 2115. https://doi.org/10.3390/polym13132115

AMA Style

Pérez Davila S, González Rodríguez L, Chiussi S, Serra J, González P. How to Sterilize Polylactic Acid Based Medical Devices? Polymers. 2021; 13(13):2115. https://doi.org/10.3390/polym13132115

Chicago/Turabian Style

Pérez Davila, Sara, Laura González Rodríguez, Stefano Chiussi, Julia Serra, and Pío González. 2021. "How to Sterilize Polylactic Acid Based Medical Devices?" Polymers 13, no. 13: 2115. https://doi.org/10.3390/polym13132115

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