Fabrication of Flexible pH-Responsive Agarose/Succinoglycan Hydrogels for Controlled Drug Release
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials
2.2. Preparation of Agarose/Succinoglycan Hydrogels
2.3. Rheological Measurements
2.4. Attenuated Total Reflection–Fourier Transform Infrared (ATR-FTIR) Spectroscopy
2.5. X-ray Diffraction (XRD) Measurements
2.6. Field Emission Scanning Electron Microscopy (FE-SEM) Analysis
2.7. Swelling Tests
2.8. In Vitro Drug Loading and Release Studies
2.9. In Vitro Cytotoxicity
3. Result and Discussion
3.1. Rheological Analysis
3.2. Sol–Gel Transition Studies
3.3. Attenuated Total Reflection–Fourier Transform Infrared (ATR-FTIR) Spectra Analysis
3.4. X-ray Diffraction (XRD) Analysis
3.5. Field Emission Scanning Electron (FE-SEM) Micrograph Analysis
3.6. Swelling Behavior of Agarose/Succinoglycan Hydrogels
3.7. In Vitro Ciprofloxacin Release Study
3.8. Cytotoxicity of Agarose/Succinoglycan Hydrogels
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Hydrogels | Agarose (mL) | Succinoglycan (mL) | Agarose (%, w/v) | Succinoglycan (%, w/v) |
---|---|---|---|---|
AG10 | 10 | 0 | 2 | 0 |
AG8/SG2 | 8 | 2 | 1.6 | 0.4 |
AG6/SG4 | 6 | 4 | 1.2 | 0.8 |
AG4/SG6 | 4 | 6 | 0.8 | 1.2 |
AG2/SG8 | 2 | 8 | 0.4 | 1.6 |
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Hu, Y.; Kim, Y.; Hong, I.; Kim, M.; Jung, S. Fabrication of Flexible pH-Responsive Agarose/Succinoglycan Hydrogels for Controlled Drug Release. Polymers 2021, 13, 2049. https://doi.org/10.3390/polym13132049
Hu Y, Kim Y, Hong I, Kim M, Jung S. Fabrication of Flexible pH-Responsive Agarose/Succinoglycan Hydrogels for Controlled Drug Release. Polymers. 2021; 13(13):2049. https://doi.org/10.3390/polym13132049
Chicago/Turabian StyleHu, Yiluo, Yohan Kim, Inki Hong, Moosung Kim, and Seunho Jung. 2021. "Fabrication of Flexible pH-Responsive Agarose/Succinoglycan Hydrogels for Controlled Drug Release" Polymers 13, no. 13: 2049. https://doi.org/10.3390/polym13132049