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Article

Impact of Ergothioneine, Hercynine, and Histidine on Oxidative Degradation of Hyaluronan and Wound Healing

1
Centre of Experimental Medicine, Institute of Experimental Pharmacology and Toxicology, 84104 Bratislava, Slovakia
2
Department of Pathology, St. Elizabeth Cancer Institute Hospital, 81250 Bratislava, Slovakia
3
School of Engineering, Bernal Institute, University of Limerick, V94T9PX Limerick, Ireland
4
National Agricultural and Food Centre–RIAP Nitra, 95141 Luzianky, Slovakia
*
Author to whom correspondence should be addressed.
Polymers 2021, 13(1), 95; https://doi.org/10.3390/polym13010095
Received: 1 December 2020 / Revised: 18 December 2020 / Accepted: 23 December 2020 / Published: 29 December 2020
(This article belongs to the Special Issue Polymers in Biomedical Engineering)
A high-molecular weight hyaluronan is oxidatively degraded by Cu(II) ions and ascorbate—the so called Weissberger biogenic oxidative system—which is one of the most potent generators of reactive oxygen species, namely OH radicals. Ergothioneine, hercynine, or histidine were loaded into chitosan/hyaluronan composite membranes to examine their effect on skin wound healing in ischemic rabbits. We also explored the ability of ergothioneine, hercynine, or histidine to inhibit hyaluronan degradation. Rotational viscometry showed that ergothioneine decreased the degree of hyaluronan radical degradation in a dose-dependent manner. While histidine was shown to be potent in scavenging OH radicals, however, hercynine was ineffective. In vivo results showed that the addition of each investigated agent to chitosan/hyaluronan membranes contributed to a more potent treatment of ischemic skin wounds in rabbits compared to untreated animals and animals treated only with chitosan/hyaluronan membranes. View Full-Text
Keywords: free/OH radicals; rotational viscometry; skin injuries; thiol compounds free/OH radicals; rotational viscometry; skin injuries; thiol compounds
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MDPI and ACS Style

Valachova, K.; Svik, K.; Biro, C.; Collins, M.N.; Jurcik, R.; Ondruska, L.; Soltes, L. Impact of Ergothioneine, Hercynine, and Histidine on Oxidative Degradation of Hyaluronan and Wound Healing. Polymers 2021, 13, 95. https://doi.org/10.3390/polym13010095

AMA Style

Valachova K, Svik K, Biro C, Collins MN, Jurcik R, Ondruska L, Soltes L. Impact of Ergothioneine, Hercynine, and Histidine on Oxidative Degradation of Hyaluronan and Wound Healing. Polymers. 2021; 13(1):95. https://doi.org/10.3390/polym13010095

Chicago/Turabian Style

Valachova, Katarina; Svik, Karol; Biro, Csaba; Collins, Maurice N.; Jurcik, Rastislav; Ondruska, Lubomir; Soltes, Ladislav. 2021. "Impact of Ergothioneine, Hercynine, and Histidine on Oxidative Degradation of Hyaluronan and Wound Healing" Polymers 13, no. 1: 95. https://doi.org/10.3390/polym13010095

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