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Article

Solvent-Free Processing of Drug-Loaded Poly(ε-Caprolactone) Scaffolds with Tunable Macroporosity by Combination of Supercritical Foaming and Thermal Porogen Leaching

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Department of Pharmacology, Pharmacy and Pharmaceutical Technology, I + D Farma Group (GI-1645), Faculty of Pharmacy and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, E-15782 Santiago de Compostela, Spain
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BioFarma Research Group, Centro Singular de Investigación en Medicina Molecular y Enfermedades Crónicas (CiMUS), Universidade de Santiago de Compostela, E-15782 Santiago de Compostela, Spain
*
Author to whom correspondence should be addressed.
The work described in this paper is the subject of patent number WO2017013288A1 led by Universidade de Santiago de Compostela.
Polymers 2021, 13(1), 159; https://doi.org/10.3390/polym13010159
Received: 3 December 2020 / Revised: 27 December 2020 / Accepted: 30 December 2020 / Published: 4 January 2021
(This article belongs to the Special Issue Polymeric Materials as Scaffolds for Tissue Engineering)
Demand of scaffolds for hard tissue repair increases due to a higher incidence of fractures related to accidents and bone-diseases that are linked to the ageing of the population. Namely, scaffolds loaded with bioactive agents can facilitate the bone repair by favoring the bone integration and avoiding post-grafting complications. Supercritical (sc-)foaming technology emerges as a unique solvent-free approach for the processing of drug-loadenu7d scaffolds at high incorporation yields. In this work, medicated poly(ε-caprolactone) (PCL) scaffolds were prepared by sc-foaming coupled with a leaching process to overcome problems of pore size tuning of the sc-foaming technique. The removal of the solid porogen (BA, ammonium bicarbonate) was carried out by a thermal leaching taking place at 37 °C and in the absence of solvents for the first time. Macroporous scaffolds with dual porosity (50–100 µm and 200–400 µm ranges) were obtained and with a porous structure directly dependent on the porogen content used. The processing of ketoprofen-loaded scaffolds using BA porogen resulted in drug loading yields close to 100% and influenced its release profile from the PCL matrix to a relevant clinical scenario. A novel solvent-free strategy has been set to integrate the incorporation of solid porogens in the sc-foaming of medicated scaffolds. View Full-Text
Keywords: scaffolds; supercritical CO2; foaming; solvent-free processing; ketoprofen; porogen scaffolds; supercritical CO2; foaming; solvent-free processing; ketoprofen; porogen
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MDPI and ACS Style

Santos-Rosales, V.; Ardao, I.; Goimil, L.; Gomez-Amoza, J.L.; García-González, C.A. Solvent-Free Processing of Drug-Loaded Poly(ε-Caprolactone) Scaffolds with Tunable Macroporosity by Combination of Supercritical Foaming and Thermal Porogen Leaching. Polymers 2021, 13, 159. https://doi.org/10.3390/polym13010159

AMA Style

Santos-Rosales V, Ardao I, Goimil L, Gomez-Amoza JL, García-González CA. Solvent-Free Processing of Drug-Loaded Poly(ε-Caprolactone) Scaffolds with Tunable Macroporosity by Combination of Supercritical Foaming and Thermal Porogen Leaching. Polymers. 2021; 13(1):159. https://doi.org/10.3390/polym13010159

Chicago/Turabian Style

Santos-Rosales, Víctor, Inés Ardao, Leticia Goimil, Jose L. Gomez-Amoza, and Carlos A. García-González 2021. "Solvent-Free Processing of Drug-Loaded Poly(ε-Caprolactone) Scaffolds with Tunable Macroporosity by Combination of Supercritical Foaming and Thermal Porogen Leaching" Polymers 13, no. 1: 159. https://doi.org/10.3390/polym13010159

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