Next Article in Journal
Thermoreversible Polymer Gels in DMF Formed from Charge- and Crystallization-Induced Assembly
Next Article in Special Issue
Preparation of Hybrid Alginate-Chitosan Aerogel as Potential Carriers for Pulmonary Drug Delivery
Previous Article in Journal
Coalescence of Binary Droplets in the Transformer Oil Based on Small Amounts of Polymer: Effects of Initial Droplet Diameter and Collision Parameter
Previous Article in Special Issue
Experimental Investigation and CFD Modeling of Supercritical Adsorption Process
Article

Chitosan-Based Aerogel Particles as Highly Effective Local Hemostatic Agents. Production Process and In Vivo Evaluations

1
International Center for transfer of Pharmaceutical and Biotechnology, Mendeleev University of Chemical Technology of Russia, 125047 Moscow, Russia
2
Department of Pharmaceutical Chemistry, Saint Petersburg State Chemical Pharmaceutical University, 197376 Saint Petersburg, Russia
*
Author to whom correspondence should be addressed.
Polymers 2020, 12(9), 2055; https://doi.org/10.3390/polym12092055
Received: 3 August 2020 / Revised: 4 September 2020 / Accepted: 8 September 2020 / Published: 10 September 2020
Chitosan aerogels with potential applications as effective local hemostatic agents were prepared using supercritical carbon dioxide drying to preserve the chitosan network structure featuring high internal surfaces and porosities of up to 300 m²/g and 98%, respectively. For the first time, hemostatic efficacy of chitosan-based aerogel particles was studied in vivo on a model of damage of a large vessel in the deep wound. Pigs were used as test animals. It was shown that primary hemostasis was achieved, there were no signs of rebleeding and aerogel particles were tightly fixed to the walls of the wound canal. A dense clot was formed inside the wound (at the femoral artery), which indicates stable hemostasis. This study demonstrated that chitosan-based aerogel particles have a high sorption capacity and are highly effective as local hemostatic agents which can be used to stop massive bleeding. View Full-Text
Keywords: aerogels; chitosan; blood sorption; in vivo evaluations; local hemostatic agent aerogels; chitosan; blood sorption; in vivo evaluations; local hemostatic agent
Show Figures

Graphical abstract

MDPI and ACS Style

Lovskaya, D.; Menshutina, N.; Mochalova, M.; Nosov, A.; Grebenyuk, A. Chitosan-Based Aerogel Particles as Highly Effective Local Hemostatic Agents. Production Process and In Vivo Evaluations. Polymers 2020, 12, 2055. https://doi.org/10.3390/polym12092055

AMA Style

Lovskaya D, Menshutina N, Mochalova M, Nosov A, Grebenyuk A. Chitosan-Based Aerogel Particles as Highly Effective Local Hemostatic Agents. Production Process and In Vivo Evaluations. Polymers. 2020; 12(9):2055. https://doi.org/10.3390/polym12092055

Chicago/Turabian Style

Lovskaya, Daria; Menshutina, Natalia; Mochalova, Maria; Nosov, Artem; Grebenyuk, Alexander. 2020. "Chitosan-Based Aerogel Particles as Highly Effective Local Hemostatic Agents. Production Process and In Vivo Evaluations" Polymers 12, no. 9: 2055. https://doi.org/10.3390/polym12092055

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop