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Ciprofloxacin-Collagen-Based Materials with Potential Oral Surgical Applications

Department of General Chemistry, Faculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, 1-7 Gh. Polizu Str., 011061 Bucharest, Romania
Department of Collagen, National Research and Development Institute for Textile and Leather (INCDTP), Division Leather and Footwear Research Institute, 93 Ion Minulescu Str., 031215 Bucharest, Romania
Faculty of Biotechnology, University of Agronomic Sciences and Veterinary Medicine of Bucharest, 54 Marasti Boulevard, 011464 Bucharest, Romania
Biotechnology Department, National Institute for Chemistry and Petrochemistry R&D of Bucharest, 202 Splaiul Independentei, 060021 Bucharest, Romania
Institute of Virology Stefan S. Nicolau, Immunology Centre, 285 Mihai Bravu Avenue, 030304 Bucharest, Romania
Department of Physical and Colloidal Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy “Carol Davila”, 6 Traian Vuia Str., 020956 Bucharest, Romania
Author to whom correspondence should be addressed.
Polymers 2020, 12(9), 1915;
Received: 11 July 2020 / Revised: 19 August 2020 / Accepted: 21 August 2020 / Published: 25 August 2020
(This article belongs to the Special Issue Biopolymers for Medicinal, Macromolecules, and Food Applications)
We report in this paper the synthesis and characterization of a new collagen-based material. This material was obtained in a spongy form and was functionalized with an antibiotic, ciprofloxacin. The targeted applications of these kind of materials concern the post-operative prophylaxis. The in vitro tests (antimicrobial, cytotoxic, drug release) showed that sponges with a concentration of 0.75 g of ciprofloxacin per gram of collagen could be beneficial for the desired applications. View Full-Text
Keywords: ciprofloxacin; collagen-based materials; cytotoxicity; drug release ciprofloxacin; collagen-based materials; cytotoxicity; drug release
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MDPI and ACS Style

Ioan, D.-C.; Rău, I.; Albu Kaya, M.G.; Radu, N.; Bostan, M.; Zgârian, R.G.; Tihan, G.T.; Dinu-Pîrvu, C.-E.; Lupuliasa, A.; Ghica, M.V. Ciprofloxacin-Collagen-Based Materials with Potential Oral Surgical Applications. Polymers 2020, 12, 1915.

AMA Style

Ioan D-C, Rău I, Albu Kaya MG, Radu N, Bostan M, Zgârian RG, Tihan GT, Dinu-Pîrvu C-E, Lupuliasa A, Ghica MV. Ciprofloxacin-Collagen-Based Materials with Potential Oral Surgical Applications. Polymers. 2020; 12(9):1915.

Chicago/Turabian Style

Ioan, Daniel-Cristian, Ileana Rău, Mădălina G. Albu Kaya, Nicoleta Radu, Marinela Bostan, Roxana G. Zgârian, Graţiela T. Tihan, Cristina-Elena Dinu-Pîrvu, Alina Lupuliasa, and Mihaela V. Ghica 2020. "Ciprofloxacin-Collagen-Based Materials with Potential Oral Surgical Applications" Polymers 12, no. 9: 1915.

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