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Article

Ciprofloxacin-Collagen-Based Materials with Potential Oral Surgical Applications

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Department of General Chemistry, Faculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, 1-7 Gh. Polizu Str., 011061 Bucharest, Romania
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Department of Collagen, National Research and Development Institute for Textile and Leather (INCDTP), Division Leather and Footwear Research Institute, 93 Ion Minulescu Str., 031215 Bucharest, Romania
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Faculty of Biotechnology, University of Agronomic Sciences and Veterinary Medicine of Bucharest, 54 Marasti Boulevard, 011464 Bucharest, Romania
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Biotechnology Department, National Institute for Chemistry and Petrochemistry R&D of Bucharest, 202 Splaiul Independentei, 060021 Bucharest, Romania
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Institute of Virology Stefan S. Nicolau, Immunology Centre, 285 Mihai Bravu Avenue, 030304 Bucharest, Romania
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Department of Physical and Colloidal Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy “Carol Davila”, 6 Traian Vuia Str., 020956 Bucharest, Romania
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Author to whom correspondence should be addressed.
Polymers 2020, 12(9), 1915; https://doi.org/10.3390/polym12091915
Received: 11 July 2020 / Revised: 19 August 2020 / Accepted: 21 August 2020 / Published: 25 August 2020
(This article belongs to the Special Issue Biopolymers for Medicinal, Macromolecules, and Food Applications)
We report in this paper the synthesis and characterization of a new collagen-based material. This material was obtained in a spongy form and was functionalized with an antibiotic, ciprofloxacin. The targeted applications of these kind of materials concern the post-operative prophylaxis. The in vitro tests (antimicrobial, cytotoxic, drug release) showed that sponges with a concentration of 0.75 g of ciprofloxacin per gram of collagen could be beneficial for the desired applications. View Full-Text
Keywords: ciprofloxacin; collagen-based materials; cytotoxicity; drug release ciprofloxacin; collagen-based materials; cytotoxicity; drug release
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MDPI and ACS Style

Ioan, D.-C.; Rău, I.; Albu Kaya, M.G.; Radu, N.; Bostan, M.; Zgârian, R.G.; Tihan, G.T.; Dinu-Pîrvu, C.-E.; Lupuliasa, A.; Ghica, M.V. Ciprofloxacin-Collagen-Based Materials with Potential Oral Surgical Applications. Polymers 2020, 12, 1915. https://doi.org/10.3390/polym12091915

AMA Style

Ioan D-C, Rău I, Albu Kaya MG, Radu N, Bostan M, Zgârian RG, Tihan GT, Dinu-Pîrvu C-E, Lupuliasa A, Ghica MV. Ciprofloxacin-Collagen-Based Materials with Potential Oral Surgical Applications. Polymers. 2020; 12(9):1915. https://doi.org/10.3390/polym12091915

Chicago/Turabian Style

Ioan, Daniel-Cristian, Ileana Rău, Mădălina G. Albu Kaya, Nicoleta Radu, Marinela Bostan, Roxana G. Zgârian, Graţiela T. Tihan, Cristina-Elena Dinu-Pîrvu, Alina Lupuliasa, and Mihaela V. Ghica 2020. "Ciprofloxacin-Collagen-Based Materials with Potential Oral Surgical Applications" Polymers 12, no. 9: 1915. https://doi.org/10.3390/polym12091915

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