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Open AccessArticle

Efficacy of A Novel Smart Polymeric Nanodrug in the Treatment of Experimental Wounds in Rats

1
Department of Human Pathology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Trubetskaya Str, 8, 119991 Moscow, Russia
2
Department of Plastic and Reconstructive Surgery, Cosmetology and Cell Technologies, N.I. Pirogov Russian National Research Medical University (RNRMU), Ostrovityanova St., 1, 117997 Moscow, Russia
3
Department of Hospital Surgery №1, N.I. Pirogov Russian National Research Medical University (RNRMU), Ostrovityanova St., 1, 117997 Moscow, Russia
4
Research Institute of Experimental Medicine, Kursk State Medical University, Karl Marx St, 3, 305041 Kursk, Russia
5
Department of Histology, Embryology, Cytology, Kursk State Medical University, Karl Marx St, 3, 305041 Kursk, Russia
*
Author to whom correspondence should be addressed.
Polymers 2020, 12(5), 1126; https://doi.org/10.3390/polym12051126
Received: 1 April 2020 / Revised: 23 April 2020 / Accepted: 11 May 2020 / Published: 14 May 2020
(This article belongs to the Special Issue Smart Polymeric Nanoparticles for Applications in Nanomedicine)
High-quality and aesthetic wound healing, as well as effective medical support of this process, continue to be relevant. This study aims to evaluate the medical efficacy of a novel smart polymeric nanodrug (SPN) on the rate and mechanism of wound healing in experimental animals. The study was carried out in male Wistar rats (aged 8–9 months). In these animals, identical square wounds down to the fascia were made in non-sterile conditions on the back on both sides of the vertebra. SPN was used for the treatment of one wound, and the other wound was left without treatment (control group). Biocompatible citrate-stabilized cerium oxide nanoparticles integrated into a polysaccharide hydrogel matrix containing natural and synthetic polysaccharide polymers (pectin, alginate, chitosan, agar-agar, water-soluble cellulose derivatives) were used as the therapeutic agent. Changes in the wound sizes (area, volume) over time and wound temperature were assessed on Days 0, 1, 3, 5, 7, and 14. Histological examination of the wounds was performed on Days 3, 7, and 14. The study showed that the use of SPN accelerated wound healing in comparison with control wounds by inhibiting the inflammatory response, which was measured by a decreased number of white blood cells in SPN-treated wounds. It also accelerated the development of fibroblasts, with an early onset of new collagen synthesis, which eventually led to the formation of more tender postoperative scars. Thus, the study demonstrated that the use of SPN for the treatment of wounds was effective and promising. View Full-Text
Keywords: nanomedicine; smart polymeric nanodrug; nanoparticles; cerium dioxide; skin wounds; wound healing; experimental study; rat nanomedicine; smart polymeric nanodrug; nanoparticles; cerium dioxide; skin wounds; wound healing; experimental study; rat
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Silina, E.V.; Manturova, N.E.; Vasin, V.I.; Artyushkova, E.B.; Khokhlov, N.V.; Ivanov, A.V.; Stupin, V.A. Efficacy of A Novel Smart Polymeric Nanodrug in the Treatment of Experimental Wounds in Rats. Polymers 2020, 12, 1126.

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