Morphology Dependence Degradation of Electro- and Magnetoactive Poly(3-hydroxybutyrate-co-hydroxyvalerate) for Tissue Engineering Applications

Amaro, Luis; Correia, Daniela M.; Martins, Pedro M.; Botelho, Gabriela; Carabineiro, Sónia A. C.; Ribeiro, Clarisse; Lanceros-Mendez, Senentxu

doi:10.3390/polym12040953

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Morphology Dependence Degradation of Electro- and Magnetoactive Poly(3-hydroxybutyrate-co-hydroxyvalerate) for Tissue Engineering Applications

^1,†,

^1,2,†

Sónia A. C. Carabineiro

⁴

Clarisse Ribeiro

^1,5,*

and

Senentxu Lanceros-Mendez

^6,7

Center of Physics, Universidade do Minho, 4710-057 Braga, Portugal

Center of Chemistry, Universidade de Trás-os-Montes e Alto Douro, 5001-801 Vila Real, Portugal

Department of Chemistry, Universidade do Minho, 4710-057 Braga, Portugal

⁴

LAQV-REQUIMTE, Department of Chemistry, NOVA School of Science and Technology, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal

⁵

CEB—Centre of Biological Engineering, University of Minho, 4710-057 Braga, Portugal

⁶

BCMaterials, Basque Center for Materials, Applications and Nanostructures, UPV/EHU Science Park, 48940 Leioa, Spain

⁷

IKERBASQUE, Basque Foundation for Science, 48013 Bilbao, Spain

Author to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Polymers 2020, 12(4), 953; https://doi.org/10.3390/polym12040953

Received: 25 March 2020 / Revised: 9 April 2020 / Accepted: 16 April 2020 / Published: 20 April 2020

(This article belongs to the Special Issue Advanced Polymeric Biomaterials for Tissue Engineering)

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Abstract

Poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) is a piezoelectric biodegradable and biocompatible polymer suitable for tissue engineering applications. The incorporation of magnetostrictive cobalt ferrites (CFO) into PHBV matrix enables the production of magnetically responsive composites, which proved to be effective in the differentiation of a variety of cells and tissues. In this work, PHBV and PHBV with CFO nanoparticles were produced in the form of films, fibers and porous scaffolds and subjected to an experimental program allowing to evaluate the degradation process under biological conditions for a period up to 8 weeks. The morphology, physical, chemical and thermal properties were evaluated, together with the weight loss of the samples during the in vitro degradation assays. No major changes in the mentioned properties were found, thus proving its applicability for tissue engineering applications. Degradation was apparent from week 4 and onwards, leading to the conclusion that the degradation ratio of the material is suitable for a large range of tissue engineering applications. Further, it was found that the degradation of the samples maintain the biocompatibility of the materials for the pristine polymer, but can lead to cytotoxic effects when the magnetic CFO nanoparticles are exposed, being therefore needed, for magnetoactive applications, to substitute them by biocompatible ferrites, such as an iron oxide (Fe₃O₄). View Full-Text

Keywords: piezoelectric materials; poly(hydroxybutyrate-co-hydroxyvalerate); hydrolytic degradation; tissue engineering

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MDPI and ACS Style

Amaro, L.; Correia, D.M.; Martins, P.M.; Botelho, G.; Carabineiro, S.A.C.; Ribeiro, C.; Lanceros-Mendez, S. Morphology Dependence Degradation of Electro- and Magnetoactive Poly(3-hydroxybutyrate-co-hydroxyvalerate) for Tissue Engineering Applications. Polymers 2020, 12, 953. https://doi.org/10.3390/polym12040953

AMA Style

Amaro L, Correia DM, Martins PM, Botelho G, Carabineiro SAC, Ribeiro C, Lanceros-Mendez S. Morphology Dependence Degradation of Electro- and Magnetoactive Poly(3-hydroxybutyrate-co-hydroxyvalerate) for Tissue Engineering Applications. Polymers. 2020; 12(4):953. https://doi.org/10.3390/polym12040953

Chicago/Turabian Style

Amaro, Luis, Daniela M. Correia, Pedro M. Martins, Gabriela Botelho, Sónia A.C. Carabineiro, Clarisse Ribeiro, and Senentxu Lanceros-Mendez. 2020. "Morphology Dependence Degradation of Electro- and Magnetoactive Poly(3-hydroxybutyrate-co-hydroxyvalerate) for Tissue Engineering Applications" Polymers 12, no. 4: 953. https://doi.org/10.3390/polym12040953

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Morphology Dependence Degradation of Electro- and Magnetoactive Poly(3-hydroxybutyrate-co-hydroxyvalerate) for Tissue Engineering Applications

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