Next Article in Journal
Continuous Two-Domain Equations of State for the Description of the Pressure-Specific Volume-Temperature Behavior of Polymers
Previous Article in Journal
Application of Eco-Friendly Waterborne Polyurethane Composite Coating Incorporated with Nano Cellulose Crystalline and Silver Nano Particles on Wood Antibacterial Board
Open AccessArticle

Fabrication of Carboxylmethyl Chitosan Nanocarrier via Self-Assembly for Efficient Delivery of Phenylethyl Resorcinol in B16 Cells

by Pei Zhang 1,2, Huixia Guo 2 and Chenguang Liu 1,*
1
College of Marine Life Sciences, Ocean University of China, Qingdao 266003, China
2
Department of Life Science, Luoyang Normal University, Luoyang 471022, China
*
Author to whom correspondence should be addressed.
Polymers 2020, 12(2), 408; https://doi.org/10.3390/polym12020408
Received: 19 January 2020 / Revised: 30 January 2020 / Accepted: 31 January 2020 / Published: 11 February 2020
Micro-molecular drugs have special advantages to cope with challenging diseases, however their structure, physical and chemical properties, stability, and pharmacodynamics have more requirements for the way they are delivered into the body. Carrier-based drug delivery systems can circumvent many limited factors of drug delivery and increase their bioavailability. In this context, stable drug nanocarriers of alkaline amino acids (arginine, Arg) modified conjugated linoleic acid-carboxymethyl chitosan (CLA-CMCS) conjugate were developed, which could generate supramolecular micelles to effectively encapsulate the tyrosinase inhibitor phenylethyl resorcinol (PR). The resulting CCA-NPs were spherical nanoparticles with a mean size around 175 nm. The 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay and cellular uptake investigation demonstrated that the CCA-NPs were non-cytotoxic and had excellent cell transport ability. In addition, these CCA-NPs were able to effectively deliver PR and inhibited melanin formation to reduce pigmentation by enhancing cellular uptake. In conclusion, our research indicated that nanocarriers based on self-assembly amphiphilic polymers constituted a promising and effective drug delivery system in hyperpigmentation targeting.
Keywords: carboxymethyl chitosan; self-assembly; nanocarrier; phenylethyl resorcinol; cellular uptake; hyperpigmentation carboxymethyl chitosan; self-assembly; nanocarrier; phenylethyl resorcinol; cellular uptake; hyperpigmentation
MDPI and ACS Style

Zhang, P.; Guo, H.; Liu, C. Fabrication of Carboxylmethyl Chitosan Nanocarrier via Self-Assembly for Efficient Delivery of Phenylethyl Resorcinol in B16 Cells. Polymers 2020, 12, 408.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop