New Insight into the Mechanism of Drug Release from Poly(d,l-lactide) Film by Electron Paramagnetic Resonance
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials and Substances
2.2. Samples Preparation
2.3. Release Experiments
2.4. EPR Spectroscopy
2.4.1. Spectra Recording
2.4.2. Numerical Analysis of EPR Spectra
3. Results and Discussion
3.1. Physicochemical Characterization of the Samples
3.2. Kinetic Regularities of the Dopants Release from the Poly(d,l-lactide) Films
3.3. Mathematical Modeling of the Release Process
- (1)
- The dry polymer film is structurally uniform.
- (2)
- The dopant is distributed uniformly in a dry sample.
- (3)
- Diffusion through the side surface of the film is negligible.
- (4)
- Perfect-sink conditions are used.
4. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Mn | Mw | Đ | |
---|---|---|---|
PDL 04 | 14,800 | 36,100 | 2.4 |
PDL 04, after SCF processing | 15,200 | 35,800 | 2.4 |
PDL 02 | 7200 | 15,600 | 2.2 |
Time | Average Number of Pores per 100 μm2 |
---|---|
2 h | 16 |
2 days | 7 |
4 days | 8 |
6 days | 4 |
9 days | 8 |
11 days | 10 |
System | D0, m2·Day−1 | , m−1 | , Day−1 | , Day | A, m2·Day−5/2 | ||
---|---|---|---|---|---|---|---|
1 | TEMPOL/200 μm | 7.5 × 10−11 | 5.0 × 104 | 1.4 | 0.5 | 6.1 | 1.35 × 10−11 |
1 | TEMPOL/200 μm | 7.5 × 10−11 | 2.5 × 104 | 1.0 | 0.3 | 5.9 | 0.94 × 10−11 |
2 | TEMPOL/50 μm | 2.4 × 10−11 | 0.9 × 104 | 0.33 | 1.0 | 2.6 | 4.77 × 10−13 |
3 | ATI/200 μm | 6.9 × 10−11 | 1.4 × 104 | 0.17 | 0.9 | 5.8 | 1.11 × 10−11 |
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Chumakova, N.A.; Golubeva, E.N.; Kuzin, S.V.; Ivanova, T.A.; Grigoriev, I.A.; Kostjuk, S.V.; Melnikov, M.Y. New Insight into the Mechanism of Drug Release from Poly(d,l-lactide) Film by Electron Paramagnetic Resonance. Polymers 2020, 12, 3046. https://doi.org/10.3390/polym12123046
Chumakova NA, Golubeva EN, Kuzin SV, Ivanova TA, Grigoriev IA, Kostjuk SV, Melnikov MY. New Insight into the Mechanism of Drug Release from Poly(d,l-lactide) Film by Electron Paramagnetic Resonance. Polymers. 2020; 12(12):3046. https://doi.org/10.3390/polym12123046
Chicago/Turabian StyleChumakova, Natalia A., Elena N. Golubeva, Sergei V. Kuzin, Tatiana A. Ivanova, Igor A. Grigoriev, Sergey V. Kostjuk, and Mikhail Ya. Melnikov. 2020. "New Insight into the Mechanism of Drug Release from Poly(d,l-lactide) Film by Electron Paramagnetic Resonance" Polymers 12, no. 12: 3046. https://doi.org/10.3390/polym12123046