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Open AccessArticle

Electrospun Bioresorbable Membrane Eluting Chlorhexidine for Dental Implants

1
Statice, 25000 Besançon, France
2
Science et Surface, 69130 Écully, France
3
Anthogyr, 74700 Sallanches, France
4
Univ Lyon, Université Claude Bernard Lyon1, Laboratoire des Multimatériaux et Interfaces, UMR CNRS 5615, F-69622 Villeurbanne, France
5
Namsa, 38670 Chasse-sur-Rhône, France
*
Author to whom correspondence should be addressed.
Polymers 2020, 12(1), 66; https://doi.org/10.3390/polym12010066
Received: 28 November 2019 / Revised: 19 December 2019 / Accepted: 20 December 2019 / Published: 2 January 2020
(This article belongs to the Special Issue Polymer Processing for Biomedical Purposes)
To prevent the uncontrolled development of a pathogenic biofilm around a dental implant, an antimicrobial drug-release electrospun membrane, set up between the implant and the gingival tissue, was developed by taking several technical, industrial and regulatory specifications into account. The membrane formulation is made of a blend of poly(l-lactic–co–gycolic acid) (PLGA, 85:15) and poly(l-lactic acide–co–ɛ-caprolactone) (PLC, 70:30) copolymers with chlorhexidine diacetate (CHX) complexed with β-cyclodextrin (CD). The amount of residual solvent, the mechanical properties and the drug release kinetics were tuned by the copolymers’ ratio, between 30% and 100% of PLC, and a CHX loading up to 20% w/w. The membranes were sterilized by γ-irradiation without significant property changes. The fiber′s diameter was between 600 nm and 3 µm, depending on the membrane composition and the electrospinning parameters. CHX was released in vitro over 10 days and the bacterial inhibitory concentration, 80 µg·mL−1, was reached within eight days. The optimal membrane, PGLA/PLC/CHX-CD (60%/40%/4%), exhibited a breaking strain of 50%, allowing its safe handling. This membrane and a membrane without CHX-CD were implanted subcutaneous in a rat model. The cell penetration remained low. The next step will be to increase the porosity of the membrane to improve the dynamic cell penetration and tissue remodeling. View Full-Text
Keywords: electrospinning; bioresorbable polymers; dental membrane; drug delivery; peri-implantitis electrospinning; bioresorbable polymers; dental membrane; drug delivery; peri-implantitis
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MDPI and ACS Style

Pouponneau, P.; Perrey, O.; Brunon, C.; Grossiord, C.; Courtois, N.; Salles, V.; Alves, A. Electrospun Bioresorbable Membrane Eluting Chlorhexidine for Dental Implants. Polymers 2020, 12, 66. https://doi.org/10.3390/polym12010066

AMA Style

Pouponneau P, Perrey O, Brunon C, Grossiord C, Courtois N, Salles V, Alves A. Electrospun Bioresorbable Membrane Eluting Chlorhexidine for Dental Implants. Polymers. 2020; 12(1):66. https://doi.org/10.3390/polym12010066

Chicago/Turabian Style

Pouponneau, Pierre; Perrey, Ophélie; Brunon, Céline; Grossiord, Carol; Courtois, Nicolas; Salles, Vincent; Alves, Antoine. 2020. "Electrospun Bioresorbable Membrane Eluting Chlorhexidine for Dental Implants" Polymers 12, no. 1: 66. https://doi.org/10.3390/polym12010066

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