Next Article in Journal
Highly Sensitive Graphene/Polydimethylsiloxane Composite Films near the Threshold Concentration with Biaxial Stretching
Previous Article in Journal
Synergistic Effects on Incorporation of β-Tricalcium Phosphate and Graphene Oxide Nanoparticles to Silk Fibroin/Soy Protein Isolate Scaffolds for Bone Tissue Engineering
Open AccessArticle

Electrospun Bioresorbable Membrane Eluting Chlorhexidine for Dental Implants

1
Statice, 25000 Besançon, France
2
Science et Surface, 69130 Écully, France
3
Anthogyr, 74700 Sallanches, France
4
Univ Lyon, Université Claude Bernard Lyon1, Laboratoire des Multimatériaux et Interfaces, UMR CNRS 5615, F-69622 Villeurbanne, France
5
Namsa, 38670 Chasse-sur-Rhône, France
*
Author to whom correspondence should be addressed.
Polymers 2020, 12(1), 66; https://doi.org/10.3390/polym12010066
Received: 28 November 2019 / Revised: 19 December 2019 / Accepted: 20 December 2019 / Published: 2 January 2020
(This article belongs to the Special Issue Polymer Processing for Biomedical Purposes)
To prevent the uncontrolled development of a pathogenic biofilm around a dental implant, an antimicrobial drug-release electrospun membrane, set up between the implant and the gingival tissue, was developed by taking several technical, industrial and regulatory specifications into account. The membrane formulation is made of a blend of poly(l-lactic–co–gycolic acid) (PLGA, 85:15) and poly(l-lactic acide–co–ɛ-caprolactone) (PLC, 70:30) copolymers with chlorhexidine diacetate (CHX) complexed with β-cyclodextrin (CD). The amount of residual solvent, the mechanical properties and the drug release kinetics were tuned by the copolymers’ ratio, between 30% and 100% of PLC, and a CHX loading up to 20% w/w. The membranes were sterilized by γ-irradiation without significant property changes. The fiber′s diameter was between 600 nm and 3 µm, depending on the membrane composition and the electrospinning parameters. CHX was released in vitro over 10 days and the bacterial inhibitory concentration, 80 µg·mL−1, was reached within eight days. The optimal membrane, PGLA/PLC/CHX-CD (60%/40%/4%), exhibited a breaking strain of 50%, allowing its safe handling. This membrane and a membrane without CHX-CD were implanted subcutaneous in a rat model. The cell penetration remained low. The next step will be to increase the porosity of the membrane to improve the dynamic cell penetration and tissue remodeling. View Full-Text
Keywords: electrospinning; bioresorbable polymers; dental membrane; drug delivery; peri-implantitis electrospinning; bioresorbable polymers; dental membrane; drug delivery; peri-implantitis
Show Figures

Graphical abstract

MDPI and ACS Style

Pouponneau, P.; Perrey, O.; Brunon, C.; Grossiord, C.; Courtois, N.; Salles, V.; Alves, A. Electrospun Bioresorbable Membrane Eluting Chlorhexidine for Dental Implants. Polymers 2020, 12, 66.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop