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Open AccessArticle

Electrospun Bioresorbable Membrane Eluting Chlorhexidine for Dental Implants

Statice, 25000 Besançon, France
Science et Surface, 69130 Écully, France
Anthogyr, 74700 Sallanches, France
Univ Lyon, Université Claude Bernard Lyon1, Laboratoire des Multimatériaux et Interfaces, UMR CNRS 5615, F-69622 Villeurbanne, France
Namsa, 38670 Chasse-sur-Rhône, France
Author to whom correspondence should be addressed.
Polymers 2020, 12(1), 66;
Received: 28 November 2019 / Revised: 19 December 2019 / Accepted: 20 December 2019 / Published: 2 January 2020
(This article belongs to the Special Issue Polymer Processing for Biomedical Purposes)
To prevent the uncontrolled development of a pathogenic biofilm around a dental implant, an antimicrobial drug-release electrospun membrane, set up between the implant and the gingival tissue, was developed by taking several technical, industrial and regulatory specifications into account. The membrane formulation is made of a blend of poly(l-lactic–co–gycolic acid) (PLGA, 85:15) and poly(l-lactic acide–co–ɛ-caprolactone) (PLC, 70:30) copolymers with chlorhexidine diacetate (CHX) complexed with β-cyclodextrin (CD). The amount of residual solvent, the mechanical properties and the drug release kinetics were tuned by the copolymers’ ratio, between 30% and 100% of PLC, and a CHX loading up to 20% w/w. The membranes were sterilized by γ-irradiation without significant property changes. The fiber′s diameter was between 600 nm and 3 µm, depending on the membrane composition and the electrospinning parameters. CHX was released in vitro over 10 days and the bacterial inhibitory concentration, 80 µg·mL−1, was reached within eight days. The optimal membrane, PGLA/PLC/CHX-CD (60%/40%/4%), exhibited a breaking strain of 50%, allowing its safe handling. This membrane and a membrane without CHX-CD were implanted subcutaneous in a rat model. The cell penetration remained low. The next step will be to increase the porosity of the membrane to improve the dynamic cell penetration and tissue remodeling. View Full-Text
Keywords: electrospinning; bioresorbable polymers; dental membrane; drug delivery; peri-implantitis electrospinning; bioresorbable polymers; dental membrane; drug delivery; peri-implantitis
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MDPI and ACS Style

Pouponneau, P.; Perrey, O.; Brunon, C.; Grossiord, C.; Courtois, N.; Salles, V.; Alves, A. Electrospun Bioresorbable Membrane Eluting Chlorhexidine for Dental Implants. Polymers 2020, 12, 66.

AMA Style

Pouponneau P, Perrey O, Brunon C, Grossiord C, Courtois N, Salles V, Alves A. Electrospun Bioresorbable Membrane Eluting Chlorhexidine for Dental Implants. Polymers. 2020; 12(1):66.

Chicago/Turabian Style

Pouponneau, Pierre; Perrey, Ophélie; Brunon, Céline; Grossiord, Carol; Courtois, Nicolas; Salles, Vincent; Alves, Antoine. 2020. "Electrospun Bioresorbable Membrane Eluting Chlorhexidine for Dental Implants" Polymers 12, no. 1: 66.

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