Next Article in Journal
Poly-L-lysine as an Effective and Safe Desquamation Inducer of Urinary Bladder Epithelium
Next Article in Special Issue
Fabrication and Characteristics of PCL Membranes Containing Strontium-Substituted Hydroxyapatite Nanofibers for Guided Bone Regeneration
Previous Article in Journal
Application of Xanthan Gum as a Pre-Treatment and Sharpness Evaluation for Inkjet Printing on Polyester
Article

Simonkolleite Coating on Poly(Amino Acids) to Improve Osteogenesis and Suppress Osteoclast Formation in Vitro

1
College of Physics, Sichuan University, Chengdu 610065, China
2
Collaborative Innovation Center of Tissue Repair Material of Sichuan Province, College of Life Sciences, China West Normal University, Nanchong 637009, China
3
Chengdu Customs Technology Center, Chengdu 610041, China
4
College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
*
Author to whom correspondence should be addressed.
Polymers 2019, 11(9), 1505; https://doi.org/10.3390/polym11091505
Received: 30 July 2019 / Revised: 1 September 2019 / Accepted: 12 September 2019 / Published: 16 September 2019
(This article belongs to the Special Issue Polymers for Bone Tissue Engineering)
Zinc can enhance osteoblastic bone formation and stimulate osteogenic differentiation, suppress the differentiation of osteoclast precursor cells into osteoclasts, and inhibit pathogenic bacterial growth in a dose-dependent manner. In this study, simonkolleite, as a novel zinc resource, was coated on poly (amino acids) (PAA) via suspending PAA powder in different concentrations of zinc chloride (ZnCl2) solution, and the simonkolleite-coated PAA (Zn–PAA) was characterized by SEM, XRD, FT-IR and XPS. Zinc ions were continuously released from the coating, and the release behavior was dependent on both the concentration of the ZnCl2 immersing solution and the type of soak solutions (SBF, PBS and DMEM). The Zn–PAA was cultured with mouse bone marrow stem cells (BMSCs) through TranswellTM plates, and the results indicated that the relative cell viability, alkaline phosphatase (ALP) activity and mineralization of BMSCs were significantly higher with Zn–PAA as compared to PAA. Moreover, the Zn–PAA was cultured with RAW264.7 cells, and the results suggested an inhibiting effect of Zn–PAA on the cell differentiation into osteoclasts. In addition, Zn–PAA exhibited an antibacterial activity against both S. aureus and E. coli. These findings suggest that simonkolleite coating with certain contents could promote osteogenesis, suppress osteoclast formation and inhibit bacteria, indicating a novel way of enhancing the functionality of synthetic bone graft material and identifying the underline principles for designing zinc-containing bone grafts. View Full-Text
Keywords: simonkolleite; coating; osteogenesis; osteoclast differentiation; bacteriostasis simonkolleite; coating; osteogenesis; osteoclast differentiation; bacteriostasis
Show Figures

Graphical abstract

MDPI and ACS Style

Li, S.; Chen, X.; Wang, X.; Xiong, Y.; Yan, Y.; Tan, Z.; Yang, X.; Li, Y. Simonkolleite Coating on Poly(Amino Acids) to Improve Osteogenesis and Suppress Osteoclast Formation in Vitro. Polymers 2019, 11, 1505. https://doi.org/10.3390/polym11091505

AMA Style

Li S, Chen X, Wang X, Xiong Y, Yan Y, Tan Z, Yang X, Li Y. Simonkolleite Coating on Poly(Amino Acids) to Improve Osteogenesis and Suppress Osteoclast Formation in Vitro. Polymers. 2019; 11(9):1505. https://doi.org/10.3390/polym11091505

Chicago/Turabian Style

Li, Shuyang, Xingtao Chen, Xiaomei Wang, Yi Xiong, Yonggang Yan, Zhi Tan, Xiaoyu Yang, and Yuanye Li. 2019. "Simonkolleite Coating on Poly(Amino Acids) to Improve Osteogenesis and Suppress Osteoclast Formation in Vitro" Polymers 11, no. 9: 1505. https://doi.org/10.3390/polym11091505

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop