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Preparation and Application of Molecularly Imprinted Monolithic Extraction Column for the Selective Microextraction of Multiple Macrolide Antibiotics from Animal Muscles

1
National Reference Laboratory of Veterinary Drug Residues (SCAU), College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China
2
Department of Ecology, College of Natural Resources and Environment, South China Agricultural University, Guangzhou 510642, China
*
Authors to whom correspondence should be addressed.
Polymers 2019, 11(7), 1109; https://doi.org/10.3390/polym11071109
Received: 18 March 2019 / Revised: 10 June 2019 / Accepted: 18 June 2019 / Published: 1 July 2019
(This article belongs to the Special Issue Molecular Imprinted Polymers: Challenges and Applications)
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Abstract

This study aimed to prepare a molecularly imprinted monolithic extraction column (MIMC) inside a micropipette tip by situ polymerization with roxithromycin as the dummy template. The polymers possessed excellent adsorption capacity and class-specificity to multiple macrolide drugs. MIMC was directly connected to a syringe for template removal and for the optimization of extraction conditions without any other post-treatment of polymers. A liquid chromatography-tandem mass spectrometric method was developed for the selective microextraction and determination of macrolide antibiotics in animal muscles based on MIMC. High recoveries of 76.1–92.8% for six macrolides were obtained with relative standard deviations less than 10.4%. MIMC exhibited better retention ability and durability when compared with the traditional C18 and HLB cartridges. The proposed method shows a great potential for the analysis of macrolide drugs at the trace level in animal foodstuffs. View Full-Text
Keywords: molecularly imprinted monolithic extraction column; microextraction; macrolide antibiotics; animal muscles; liquid chromatography-tandem mass spectrometry molecularly imprinted monolithic extraction column; microextraction; macrolide antibiotics; animal muscles; liquid chromatography-tandem mass spectrometry
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Song, X.; Zhou, T.; Zhang, J.; Su, Y.; Zhou, H.; He, L. Preparation and Application of Molecularly Imprinted Monolithic Extraction Column for the Selective Microextraction of Multiple Macrolide Antibiotics from Animal Muscles. Polymers 2019, 11, 1109.

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