Next Article in Journal
Cleavage of the Graft Bonds in PVDF–g–St Films by Boiling Xylene Extraction and the Determination of the Molecular Weight of the Graft Chains
Previous Article in Journal
Phase Inversion in PVDF Films with Enhanced Piezoresponse Through Spin-Coating and Quenching
Previous Article in Special Issue
Structure and Rheology of Polyelectrolyte Complexes in the Presence of a Hydrogen-Bonded Co-Solvent
Article Menu

Export Article

Open AccessReview

Protein–Polyelectrolyte Complexes and Micellar Assemblies

Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally to the work.
Polymers 2019, 11(7), 1097; https://doi.org/10.3390/polym11071097
Received: 11 April 2019 / Revised: 20 June 2019 / Accepted: 24 June 2019 / Published: 28 June 2019
  |  
PDF [7461 KB, uploaded 10 July 2019]
  |  

Abstract

In this review, we highlight the recent progress in our understanding of the structure, properties and applications of protein–polyelectrolyte complexes in both bulk and micellar assemblies. Protein–polyelectrolyte complexes form the basis of the genetic code, enable facile protein purification, and have emerged as enterprising candidates for simulating protocellular environments and as efficient enzymatic bioreactors. Such complexes undergo self-assembly in bulk due to a combined influence of electrostatic interactions and entropy gains from counterion release. Diversifying the self-assembly by incorporation of block polyelectrolytes has further enabled fabrication of protein–polyelectrolyte complex micelles that are multifunctional carriers for therapeutic targeted delivery of proteins such as enzymes and antibodies. We discuss research efforts focused on the structure, properties and applications of protein–polyelectrolyte complexes in both bulk and micellar assemblies, along with the influences of amphoteric nature of proteins accompanying patchy distribution of charges leading to unique phenomena including multiple complexation windows and complexation on the wrong side of the isoelectric point. View Full-Text
Keywords: complexation; self-assembly; protein delivery complexation; self-assembly; protein delivery
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Gao, S.; Holkar, A.; Srivastava, S. Protein–Polyelectrolyte Complexes and Micellar Assemblies. Polymers 2019, 11, 1097.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Polymers EISSN 2073-4360 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top