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Open AccessArticle

A Self-Adhesive Elastomeric Wound Scaffold for Sensitive Adhesion to Tissue

1
INM-Leibniz Institute for New Materials, Campus D2.2, D-66123 Saarbrücken, Germany
2
Department of Materials Science and Engineering, Saarland University, Campus D2.2, D-66123 Saarbrücken, Germany
3
Department of Otorhinolaryngology, Saarland University Medical Center, D-66421 Homburg, Germany
*
Author to whom correspondence should be addressed.
Polymers 2019, 11(6), 942; https://doi.org/10.3390/polym11060942
Received: 12 April 2019 / Revised: 21 May 2019 / Accepted: 24 May 2019 / Published: 31 May 2019
(This article belongs to the Special Issue Polymer Scaffolds for Biomedical Application)
Pressure sensitive adhesives based on silicone materials are used particularly for skin adhesion, e.g., the fixation of electrocardiogram (ECG) electrodes or wound dressings. However, adhesion to sensitive tissue structures is not sufficiently addressed due to the risk of damage or rupture. We propose an approach in which a poly-(dimethylsiloxane) (PDMS)-based soft skin adhesive (SSA) acts as cellular scaffold for wound healing. Due to the intrinsically low surface free energy of silicone elastomers, functionalization strategies are needed to promote the attachment and spreading of eukaryotic cells. In the present work, the effect of physical adsorption of three different proteins on the adhesive properties of the soft skin adhesive was investigated. Fibronectin adsorption slightly affects adhesion but significantly improves the cellular interaction of L929 murine fibroblasts with the polymeric surface. Composite films were successfully attached to explanted tympanic membranes. This demonstrates the potential of protein functionalized SSA to act as an adhesive scaffold in delicate biomedical applications. View Full-Text
Keywords: PDMS; soft skin adhesive; scaffold material; protein coating; PSA; tympanic membrane; scaffold; cells; wound dressing; self-adhesive PDMS; soft skin adhesive; scaffold material; protein coating; PSA; tympanic membrane; scaffold; cells; wound dressing; self-adhesive
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Boyadzhieva, S.; Sorg, K.; Danner, M.; Fischer, S.C.L.; Hensel, R.; Schick, B.; Wenzel, G.; Arzt, E.; Kruttwig, K. A Self-Adhesive Elastomeric Wound Scaffold for Sensitive Adhesion to Tissue. Polymers 2019, 11, 942.

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